6个STR基因座在广东潮汕地区汉族人群多态性研究  

Study of the genetics polymorphisms of 6 STRs loci in Chinese Han ethic group of Chaosan.

作　　者：邱容[1] 文富强[1] 应斌武[1] 徐丹[1] 呙恒娟[1] 陈亚娟[1] 

机构地区：[1]四川大学华西医院,四川成都610041

出　　处：《四川医学》2006年第6期551-553,共3页Sichuan Medical Journal

基　　金：国家自然科学杰出青年基金(批准号30425007)资助;国家自然科学基金(批准号30370627)资助;美国纽约CMB基金;中国博士后基金资助

摘　　要：目的调查6个STR基因座在中国广东潮汕地区汉族人群中的基因频率分布。方法应用四色荧光标记引物复合扩增技术对251名广东潮汕地区汉族无关个体血样的6个STR基因座进行多态性研究。结果在广东潮汕地区汉族人群中6个STR基因座个体识别概率在0.798到0.925之间,杂合度在0.645到0.765之间,多态性信息含量在0.567到0.758之间。6个STR个体识别概率基因座总值为0.999994。所有基因座经χ2检验符合Hard-Weinberg平衡。结论上述6个STR基因座在广东潮汕地区汉族人群中等位基因分布较好,个体识别率高,适合法医个体识别和亲子鉴定。Objective To investigate the genetics polymorphisms of 6 STR loci in Chinese Han ethic group of Guangdong. Methods Allele frequencies for 6 STR included in the AmpFISTR Cofiler kit were obtained from 251 adult unrelated indiviuals of Chinese Han ethic group in Guangdong of China. The values of power of discrimination （ PD）, power of exclusion （ PE ）, paternity index （PI）and matching probability（PM）were calculated. Results The measured values of the heterozygosity of the 6 STR loci were at 0,645 - 0. 765. The polymorphic information content （ PIC ） of 6 loci were at 0. 567 - 0. 758, power of discrimination （ PD ） were at 0. 798 - 0.925 ,X^2-Test indicated that the distribution of genotypes agreed with Hardy-Weinberg equilibrium. Conclusion Our results showed that 6 STR loci are valuable STRs loci genetic marker and useful in forensic medicine.

关 键 词：群体遗传学 汉族 STR 基因座 复合扩增 遗传多态性 

分 类 号：R394[医药卫生—医学遗传学]