溃疡性结肠炎患者组织中细胞表面趋化因子受体1、2的表达  

Expression of cell surface chemokine receptor 1 and 2 on intestinal mucosa of patients with ulcerative colitis

作　　者：丁炎波[1] 邹开芳[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,武汉市430022

出　　处：《实用医学杂志》2006年第11期1251-1252,共2页The Journal of Practical Medicine

摘　　要：目的:探讨细胞表面趋化因子受体1(CXCR1)和细胞表面趋化因子受体2(CXCR2)在溃疡性结肠炎(UC)患者组织中的表达和分布,了解其与UC发病的关系。方法:应用免疫组织化学SP法检测25例UC患者(其中活动期患者15例,缓解期患者10例)和10例结肠息肉患者(对照组)肠道活检组织中CXCR1和CXCR2的表达,对结果进行统计学分析。结果:UC活动期组中CXCR1的表达明显高于UC缓解期组和对照组,差异具有统计学意义,UC缓解期组与对照组之间的表达差异无统计学意义,CXCR1主要表达于浸润的炎性细胞和肠上皮细胞表面;CXCR2在3组均未见明显表达,组间差异无统计学意义。结论:IL-8主要通过CXCR1介导炎性细胞的浸润及炎症反应,CXCR1可能参与了上皮细胞对IL-8的反应,拮抗CXCR1可能为UC的治疗提供一种新的方法。Objective To study the expression and distribution of cell surface chemokine receptor 1 and 2（CXCR1 and CXCR2） in the mucosa of patients with ulcerative colitis （UC）, and analyze their relationship with pathogenesis of UC. Methods The intestinal tissues from twenty-five patients with UC （fifteen in active phase and ten in remission phase） and ten controls were studied by immunohistochemical method to detect the expression of CXCR1 and CXCR2. All data were analyzed with statistical program. Results The expression of CXCR1 in UC in active phase was significantly increased compared with that in UC in remission phase and controls, and there was no difference between UC in remission phase and controls. CXCR1 was mainly expressed in the membrane of the infiltrative inflammatory ceils and the intestinal epithelial ceils. CXCR2 was scarcely expressed in UC in both phases and controls, and there was no difference among the three groups. Conclusion IL-8 may mediate the infiltration of inflammatory cells mainly through CXCR1, and CXCR1 may partly involve in the response of intestinal epithelial ceils to IL-8. Antagonism to CXCR1 may provide a new method in the treatment of UC.

关 键 词：结肠炎 溃疡性 CXCR1 CXCR2 白细胞介素8 

分 类 号：R574.62[医药卫生—消化系统]