Gene Expression Pattern of Signal Transduction in Chronic Myeloid Leukemia  

作　　者：LI Huiyu JIE Shenghua GUO Tiannan HUANG Shi＇ang 

机构地区：[1]Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,Huhei, China

出　　处：《Wuhan University Journal of Natural Sciences》2006年第3期732-736,共5页武汉大学学报（自然科学英文版）

基　　金：Supported by National Basic Research Program(00CB510103)

摘　　要：To explore the transcriptional gene expression profiles of signaling pathway in Chronic myeloid leukemia （CML）, a series of cDNA microarray chips were tested. The results showed that differentially expressed genes related to singal transduction in CML were screened out and the genes involved in Phosphoinositide 3-kinases （PI3K）, Ras-MAPK （mitogen-activated protein kinase） and other signaling pathway genes simultaneously. The results also showed that most of these genes were up-expression genes , which suggested that signal transduction be overactivated in CML. Further analysis of these differentially expressed signal transduction genes will be helpful to understand the molecular mechanism of CML and find new targets of treatment.To explore the transcriptional gene expression profiles of signaling pathway in Chronic myeloid leukemia （CML）, a series of cDNA microarray chips were tested. The results showed that differentially expressed genes related to singal transduction in CML were screened out and the genes involved in Phosphoinositide 3-kinases （PI3K）, Ras-MAPK （mitogen-activated protein kinase） and other signaling pathway genes simultaneously. The results also showed that most of these genes were up-expression genes , which suggested that signal transduction be overactivated in CML. Further analysis of these differentially expressed signal transduction genes will be helpful to understand the molecular mechanism of CML and find new targets of treatment.

关 键 词：signal transduction cDNA microarray gene expression parterre chronic myeloid leukemia BCR-ABL 

分 类 号：R733.71[医药卫生—肿瘤]