桂皮醛对麻醉大鼠降血压作用的实验研究  

Experimental study on hypotensive effects of Cinnamaldehyde in anesthetized rats

作　　者：徐明[1] 余璐[2] 丁媛媛[3] 王跃民[1] 王四旺[3] 裴建明[1] 

机构地区：[1]第四军医大学基础部生理学教研室,陕西西安710032 [2]第四军医大学基础部病理学教研室,陕西西安710032 [3]第四军医大学药物研究所,陕西西安710032

出　　处：《心脏杂志》2006年第3期272-276,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(No.30370580)

摘　　要：目的观察桂皮醛降低麻醉大鼠血压的作用并分析其可能机制。方法观察不同浓度桂皮醛静脉连续给药后对麻醉大鼠心率（HR）、血压（BP）、左室收缩压（LVSP）、左室舒张压（LVDP）、左室最大压力变化速率（±dp／dtmax）血流动力学指标的影响。应用常规离体血管灌流方法，观察不同浓度桂皮醛对大鼠胸主动脉的作用。结果桂皮醛在120～360me／kg剂量范围内，能剂量依赖性地降低BP、LVSP和±dp／dtmax，且360mg／kg桂皮醛对麻醉大鼠的HR也有显著的抑制作用。离体血管灌流实验显示，桂皮醛在0．015～15mmol／L浓度范围内，可以剂量依赖性地舒张大鼠的胸主动脉。结论桂皮醛对麻醉大鼠具有显著的降血压作用，此作用可能与桂皮醛对心肌的负性变时、变力效应和舒张血管作用有关。AIM To investigate the hypotensive effects of cinnamaldehyde （CA） in anesthetized rats. METHODS Different doses of CA were administered to anesthetized rats to record heart rate, blood pressure, LVSP, LVDP and dp/dtmax. And routine blood vascular perfusion in vitro was used to determine the changes of NE-evoked contraction of rat thoracic aorta tone when different concentrations of CA were used. RESULTS Experiments in vivo indicated that CA at the range of 120 - 360 mg/kg produced a significant depressive effect on BP, LVSP, and dp/dt respectively in a dose-dependent manner in anesthetized rats. In addition, 360 mg/kg CA also significantly decreased heart rate in anesthetized rats. Vascular perfusion in vitro experiments indicated that at the concentration range of 0.015 to 15 mmol/L CA produced the dose-dependent relaxating effect on the NE-evoked contraction in rat thoracic aorta. CONCLUSION CA produces hypotensive effect in anesthetized rats, which is related to its negative inotropic and chronotropic effects on the heart and the relaxating effect in blood vessels.

关 键 词：桂皮醛 血压 血流动力学 血管 大鼠 

分 类 号：R972.4[医药卫生—药品]