人脑梗死后星形胶质细胞反应和微血管标记物相关性的研究  

Time-dependent changes of astrocytes and CD31-marked microvessels in human cerebral infarction

作　　者：王德生[1] 戚基萍[2] 李光伟[2] 吴鹤[2] 王丹丹[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,150001 [2]哈尔滨医科大学第一临床医学病理科,150001

出　　处：《中华老年医学杂志》2006年第5期343-345,共3页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(30270480);黑龙江省自然科学基金(D0203);哈尔滨市科技攻关计划项目(2004AA9CS196-4)

摘　　要：目的探讨人脑梗死灶周围组织星形胶质细胞和微血管的变化。方法应用9例因脑梗死而死亡尸检全脑标本,常规 HE 和免疫组织化学染色(SP)标记星形胶质细胞中的胶质纤维酸性蛋白(GFAP)和微血管标记物(CD31),观察星形胶质细胞和微血管的变化规律。结果以梗死灶为中心,由内到外可分4个区(0～3区);GFAP 在0区和1区表达很少,在2区和3区随缺血时间延长表达持续升高;CD31在0区无表达,在1区可见少量表达,在2区和3区随缺血时间延长表达持续升高。结论脑梗死后星形胶质细胞和微血管反应性增生,在缺血后期 GFAP、CD31广泛表达,两者在组织损伤修复重建过程中起重要作用。Ohjective To observe the time-dependent changes of astrocytes and microvessels in the ischemic core and surrounding areas. Methods Glial fibrillary acidic protein （GFAP）was measured by HE,and CD31 by immunohistochemistry as markers in post-mortem specimens from ten patients ,who died of cerebral infarction. Results Each section of the infarcted brains was divided into four areas （the area 0-3）. GFAP expressed a little in area 0 and 1, increased in a time-dependent manner in area 2 and 3; CD31 die not expressed in area 0, expressed a little in the area 1, and increased in area 2 and 3 continuously. Conclusions The proliferation of astrocytes and microvessels may play a significant role in the process of restoration after cerebral infarction.

关 键 词：脑缺血 星形细胞 血管 微循环 

分 类 号：R743.33[医药卫生—神经病学与精神病学]