放疗加GP方案化疗治疗中晚期非小细胞肺癌疗效观察  

Clinical effect of radiotherapy combined with GP regimen chemotherapy in advanced non-small cell lung cancer.

作　　者：刘小平[1] 陈谦[1] 邓怀慈[1] 

机构地区：[1]西安交通大学医学院第一附属医院,陕西西安710061

出　　处：《现代肿瘤医学》2006年第6期695-696,共2页Journal of Modern Oncology

摘　　要：目的:观察放疗加GP方案化疗治疗中晚期非小细胞肺癌的疗效及毒副反应。方法:60例符合条件的患者随机分为两组。对照组(单放组):采用单纯放疗;观察组(放化组):采用放疗加GP方案化疗,放疗常规大野DT40Gy,后缩野到肿瘤区DT24Gy。化疗吉西他滨1200mg,ivd1、8,顺铂20mg,iv2次/周,共4周。治疗结束进行评价。结果:单放组总有效率80.00%,完全缓解率23.33%,放化组总有效率93.33%,完全缓解率53.33%。放化组完全缓解率显著高于单放组(P<0.05),总有效率两组无显著性差异(P>0.05)。毒副反应以消化道反应、骨髓抑制及放射性肺炎为主。放化组消化道反应及骨髓抑制发生率高于单放组,放射性肺炎发生率两组无差异。结论:放疗加GP方案化疗治疗中晚期非小细胞肺癌近期疗效优于单纯放疗。毒副反应有所增加,但病人可以耐受。Objective：To evaluate the effect of radiotherapy combined with GP regimen chemotherapy in advanced non - small cell lung caner （NSCLC）. Methods： A total of 60 patients with NSCLC were divided randomly into two groups： 30 cases received conventional radiotherapy （control group） ; 30 cases received radiotherapy plus GP regimen chemotherapy（ experiment group）. Control group： Patients were irradiated 2.0Gy/f. 5 times a week, to a total dose of 64Gy. Experiment group ： Patients received radiotherapy same time plus GP regimen chemotherapy as follows ： gemcitabine （GEM） 1200mg iv on day 1 and 8, cisplatin （DDP） 20mg iv 2 times a week, for 4 weeks. Results： Control group：complete response （CR） was 23.33%, response rate（ CR ＋ PR） was 80.00%. Experiment group： CR was 53.33%, CR ＋ PR was 93.33%. CR of experiment group was significantly higner than that of the control group（P〈0.05）. CR ＋PR of two groups had no significant difference （P 〉0.05） . Nausea, vomit and myelosupression occurred in experiment group was significantly higher than that in control group （ P 〈 0.05 ）. Conclusion： Radiotherapy combined with GP regimen chemotherapy may significantly improve the effect of the treatment in advanced NSCLC. Toxicities are well tolerable.

关 键 词：非小细胞肺癌 放疗 化疗 吉西他滨 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]