两种新型医用钛合金的皮肤致敏试验  

Skin sensitization test of two new medical titanium alloys

作　　者：许智轩[1] 张玉梅[1] 王忠义[1] 于振涛[2] 周廉[2] 赵彦涛[1] 

机构地区：[1]西安第四军医大学口腔医学院修复科 [2]西北有色金属研究院

出　　处：《实用口腔医学杂志》2006年第3期350-352,共3页Journal of Practical Stomatology

基　　金：国家863计划资助项目(2002AA326070)

摘　　要：目的:评价TLE、TLM2种新型β型钛合金对皮肤潜在的致敏性。方法:以ISO10993-10:1995标准,采用最大剂量法,将白化豚鼠分为TLE、TLM、阳性对照(2,4-二硝基氯苯)、阴性对照(生理盐水)4组,先行预试验确定主试验各阶段的浓度,然后行主试验。在激发阶段的敷贴物去除后24、48、72h,观察记录各组动物激发部位的皮肤情况,按标准进行评分,并算出致敏率。结果:TLE、TLM新型钛合金的皮肤反应记分为0,致敏率为0。结论:在试验条件下TLE、TLM新型钛合金无潜在的皮肤致敏性。Objective ：To study the sensitization of two newly developed titanium alloys, TLE and TLM. Methods：According to ISO 10993-10：1995 standard, maximization test was conducted in guinea pig. The skin sensitization reactions, including erythema and oedema, induced by TLE, TLM, normal saline and 2,4-dinitrochlorobenzene were observed and scored respectively at 24,48 and 72 h exposure of the infusion of the materials. The allergenic rates and mean response score were calculated. Results：The allergenic rates and score of skin reaction of TLE and TLM were 0/15 and 0, those of normal saline 0/15 and 0, those of 2,4-dinitrochlo-robenzene 15/15 and 5, respectively. Conclusion： TLE and TLM both are not of sensitization.

关 键 词：钛 生物相容性 皮肤致敏试验 

分 类 号：R783.1[医药卫生—口腔医学]