823例无精子症患者的染色体畸变类型及生殖激素水平  

Chromosome aberration types and reproductive humors′s level in azoospermia patients.

作　　者：李克秋[1] 李光[1] 王春兰[1] 王砚[1] 朱平[2] 

机构地区：[1]天津医科大学生物学教研室,300070 [2]北京大学第一医院临床遗传中心

出　　处：《中国优生与遗传杂志》2006年第6期35-38,共4页Chinese Journal of Birth Health & Heredity

基　　金：天津市教委科学基金资助(20040117)

摘　　要：目的探讨无精子症患者的染色体畸变类型及性激素变化情况。方法对本室2000-2005年823例无精子症患者进行染色体核型分析并采用R IA法检测患者血浆生殖激素水平。将激素水平不同的患者分为4组进行临床分析。结果823例无精子症病人中检出染色体畸变158例,占19.2%。其中,性染色体异常152例,占96.2%,常染色体异常6例,占3.80%。性染色体数目异常中,K linefelter综合征119例,占75.30%,47,XYY 4例,占2.53%。性染包体结构畸变中46,XY,delYqtl-tel-16例,占10.12%,其它类型的性染色体结构畸变共计6例,占3.80%。性反转7例,占4.43%。各类型的染色体畸变患者的生殖檄索水平有不同的表现。823例无精子症患者中染色体核型正常者665例占80.8%。激素水平不同的4组组间比较有非常显著性差异。FSH、LH升高T降低病变在睾丸。病变不在睾丸和特发性无精子症者,各种激素值表现不一。结论对无精子症患者进行染色体与生殖激素的检测有利于鉴别无精子症的类型:染色体,尤其是性染色体畸变可导致无精子症的发生,使得生殖激素分泌异常,不同类型的染色体结构畸变患者的性激素水平存在差异;生殖激素FSti、LH、T、PRL水平可以反映无精子症患者睪丸病变部位,及受损伤的严重程度。Objective： to study chromosome aberration types and sex hormones change in azoospermia patients. Methods： chromosome karyotype analysis on 823 azoospermia patients and testing reproductbce hormones levels in patientg plasma. Results： Thcre were 158 （19. 2% ） patients with chromosome aberration in 823 azoospermia patients. In 158 eases were 152 （96. 20% ） cases with sex chromosome aberration; 6 （3.79%） cases with autosome aberration. In 152 cases with sex chromosome aberration, 119 （75.30%） with klimcfelter symptom; 4 （2. 53% ） with 47, XXY katyotype type, both klinefeher symptom and 47, XXY karyotype type belonged to sex chromosome number aberrahon; 16 （10. 12% ） with 46, XY, del Yql 1 -ter, one type of sex chromosome structure aberration, 6 cases with other types of sex chromosome structure aberration. There were 7 （4. 55 % ） patients with sex reversion. The reproductive hormones levels were difference among the different types of chromosome aberration. In 823 azoospermia patients, they were 665 （80. 8% ） cascs with normal karyotype. Patients were divided into4 groups by the hormones levels. The humor levels were obvious difference between any 2 groups. FSH and LH increased, but T reduced in the patients with testis pathological change. The humor levels were difference among patients without testis pathotogical change or specialty azoospermia. Conclusion： Chromosome and reproductive hormones test were necessary to distinguish the types of azoospertma： chromosome, especially, sex chromosome aberration can result in azoosprmia and abnormal hormone secretion. Sex hormone levels were difference among the patients with differencc types of chromosome structure aberrations ; Productive hormones FSH, LH, T, PRL levels can reflected the testis sites of pathological change and severity of damaged degree in azoospermm patients.

关 键 词：染色体畸变 无精子症 精子发生 生殖激素 

分 类 号：R698.2[医药卫生—泌尿科学]