米非司酮治疗子宫肌瘤68例临床分析  

作　　者：吴敏姣[1] 

机构地区：[1]浙江省湖州市第一人民医院,湖州313000

出　　处：《实用中西医结合临床》2006年第3期12-13,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨米非司酮治疗子宫肌瘤的临床疗效。方法:子宫肌瘤68例口服米非司酮治疗,12.5mg,每日1次,睡前口服,连服3月;应用彩色超声监测治疗前后子宫肌瘤的变化,测定血清激素水平、肝肾功能、血红蛋白,观察服药后副反应。结果:68例患者在治疗期间均出现闭经,症状缓解。子宫体积平均缩小30.05%(P<0.01),肌瘤体积平均缩小44.56%(P<0.01)。治疗后E2、P平均水平较治疗前下降(P<0.01)。停药后34例患者子宫肌瘤逐渐增大,22例患者出现潮热、恶心等轻微副反应。结论:米非司酮治疗子宫肌瘤有一定疗效,副反应小,是一种有效的保守治疗方法,但停药后易复发。Objectives：To investigate the effects of mifepristone treating Uterine Leigmyoma, Methods：68 cases with uterine Leimyoma were treated with mifepristone, 12.5 mg once a day before sleeping for 3 months. To observed change of uterine Leimyoma pre-treatmant and past-treatment by color Ultrasound and measured serous hormone levels, liver and renal function, and hemoglobin, meanwhile, the side effects of drugs were assessed.Results： 68 patients were amenorrhea with hemoylobin increasing during treatment. The mean level of serous Estrogen and progesterone dropped after treatment （P 〈0.01）. The percentage of the mean cubaye of uterus and uterine leimoyoma diminished 30.05% （P 〈0.01） and 44.56% （P〈0.01）. The volume of Leimyoma increased among 34 Patients after stoping treatment. The side effects such an flash and nausea appeared among 22 patients. Conclusions：Mifepristone is effective against uterine Leiomyma with less side effect . It＇s anecceptable conserative therapy, but the clinical symptoms arc easy to recur after stopping treatment.

关 键 词：米非司酮 子宫肌瘤 孕激素 临床分析 

分 类 号：R737.33[医药卫生—肿瘤]