微囊藻毒素污染及其促肝癌作用研究进展  

Study progress on pollution and liver cancer promotion of microcystins

作　　者：柳丽丽[1] 钟儒刚[1] 曾毅[2] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100022 [2]中国疾病预防控制中心病毒病预防控制所

出　　处：《卫生研究》2006年第3期377-379,共3页Journal of Hygiene Research

摘　　要：淡水水体的富营养化导致了蓝藻水华的普遍发生,微囊藻毒素是由蓝藻的部分藻属产生的环肽化合物,具有毒性大、分布广、结构稳定等特性,从而成为水环境中的重要潜在危害物质。微囊藻毒素已被证明具有明显的肝毒性,是肝肿瘤的促进剂之一。本文就微囊藻毒素的污染现状、肝毒性作用及其促肝癌机制等方面的研究进展进行了综述。Eutrophication of fresh water lakes and ponds has caused the occurrence of cyanobacteria. Microcystins （MCs）is a class of toxic cyclic heptapeptide, which may be produced by some strains of various blue-green algae. It has become potential hazardous material in aquatic environments for its toxic, distribution and stability. MCs has been showed to be extremely potent hepatotoxins and been viewed as a promoter of liver tumor. In this review, the pollution condition of MCs and its hepatotoxins as well as its mechanisms have been summarized.

关 键 词：微囊藻毒素 肝毒性 肝癌 促癌作用 

分 类 号：R735.7[医药卫生—肿瘤] R994.6[医药卫生—临床医学]