端粒酶对细胞周期调控和肿瘤发生的影响  

Effects of telomerase on cell cycle regulation and tumorigenesis

作　　者：严丽萍[1] 陶茂萱[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100021

出　　处：《卫生研究》2006年第3期380-383,共4页Journal of Hygiene Research

基　　金：科技部973项目(No.2002CB512900)

摘　　要：自端粒酶发现至今的十几年中,人们对其结构和功能进行了系统的研究,发现端粒酶与肿瘤发生具有明显的关联。肿瘤细胞具有细胞周期失调的共同特点,而正常细胞脱氧核糖核酸在受到损伤后能够发生细胞周期阻滞以及时修复损伤,即通过细胞关卡调控,这是保持基因组稳定的关键事件。细胞周期关卡调节异常可导致遗传改变,并可能导致细胞的恶性转化。本文就端粒酶激活、细胞周期失调对肿瘤形成的影响以及两者之间关系的研究做一综述。Since the original discovery of telomerase, a clear association with cancer has been demonstrated. Cell-cycle dysregulation is a hallmark of tumor cells. The ability of normal cells to undergo cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity. The biochemical pathways that stop the cell cycle in response to cellular stressors are called checkpoints. Defective checkpoint function results in genetic modifications that contribute to tumorigenesis. This review summarizes the current knowledge about the relation of telomerase activity, dysregulation of Cell- cycle and tumorigenesis.

关 键 词：端粒酶 细胞周期 永生化 肿瘤发生 

分 类 号：R730.1[医药卫生—肿瘤] Q55[医药卫生—临床医学]