加味四逆散治疗酒精性肝病临床研究  

Clinical Study on the Effect of Jiawei Sinisan on Alcohol Liver Diseases

作　　者：郭晓萍[1] 程宇甫 袁勤钊[3] 王国华[1] 卢志雁[1] 

机构地区：[1]大同大学医学院,山西大同037008 [2]大同市第五医院,山西大同037000 [3]山西省第三人民医院,山西太原030013

出　　处：《中国中医药信息杂志》2006年第6期13-14,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：大同市科技局资助项目(O3-2-E51)

摘　　要：目的观察加味四逆散治疗酒精性肝病的疗效。方法80例患者随机分为加味四逆散治疗组和小柴胡颗粒对照组,观察两组临床疗效及治疗前后肝功能、血脂及肝纤维化标志物等各项指标变化。结果加味四逆散可有效改善酒精性肝病患者的症状和体征,使肝功能、血脂及肝纤维化标志物等各项指标明显改善,总有效率达97.5%,综合疗效优于对照组。结论加味四逆散具有改善肝功能、调节肝内脂质代谢及抗肝纤维化作用,对酒精性肝病有良好的治疗效果。Objective To observe the clinical effect of Jiawei Sinisan （JWSNS） on patients with alcohol liver diseases. Methods 80 patients of alcohol liver diseases were divided into two groups, JWSNS and Xiaochalhu （as control） were used respectively to observe the variation of lipoprotein and the expression of hepatic fibrosis markers. Results The symptoms and indicators of patients were improved by JWSNS. The high variation of lipoprotein and the expression of hepatic fibrosis markers were obviously detected on alcohol liver diseases patients who were treated with JWSNS （with an effectivity of 97.5%）. However, patients treated with Xiaochaihu had less therapeutic effect. Conclusions JWSNS can obviously regulate the fat metabolism, resist hepatic fibrosis, and improve the symptom of patients suffering from alcohol liver diseases.

关 键 词：加味四逆散 酒精性肝病 临床研究 

分 类 号：R575[医药卫生—消化系统]