HMGB1和VEGF-C/D在结肠癌组织中的表达及与淋巴结转移之间的关系  

Correlation between high mobility group protein 1,VEGF-C/D expressions and lymph node metastasis in colon cancer

作　　者：李焱[1] 蒋勇[1] 史立群[2] 史爱学[2] 彭亦良[1] 梁后杰[1] 

机构地区：[1]第三军医大学西南医院肿瘤科,重庆400038 [2]第三军医大学西南医院病理学研究所,重庆400038

出　　处：《第三军医大学学报》2006年第11期1237-1239,共3页Journal of Third Military Medical University

摘　　要：目的探讨HMGB1和血管内皮生长因子C/D(VEGF-C/D)在人结肠癌组织中的表达及与淋巴结转移之间的关系。方法选择45例结肠癌标本,应用免疫组织化学染色方法,检测HMGB1和VEGF-C/D在人结肠癌组织中的表达,同时对其与临床病理参数的关系进行统计学分析。结果HMGB1在结肠癌组织中的阳性表达率为73.3%,其中有淋巴结转移的表达率为85.2%,无淋巴结转移的表达率为55.6%,差异有统计学意义。VEGF-C结肠癌组织中的阳性表达率为60%,其中有淋巴结转移的表达率为74%,无淋巴结转移的表达率为38.9%,二者差异显著。而且,HMGB1表达与VEGF-C表达呈正相关。结肠癌HMGB1和VEGF-C的表达水平与肿瘤细胞淋巴转移相关,而与患者的年龄、性别、分化程度等无相关性。结论HMGB1和VEGF-C的表达与结肠癌患者的淋巴结转移相关,可作为判断预后的一个观测指标。Objective To discuss the correlation between the expressions of high mobility group protein box 1 （ HMGB1 ）, VEGF-C/D and lymph node metastasis in colon cancer. Methods Forty-five colon cancer samples were stained by immunohistochemical method for VEGF-C/D, HMGB1. The correlations of VEGF-C/ D, HMGB1 expressions and lymph node metastasis were analyzed statistically. Results Positive HMGB1 expression was in 33 specimens, lymph node metastasis was in 27 specimens with 23 specimens of positive HMGB1 and non-lymph node metastasis was in 18 specimens with 10 specimens of positive HMGB1. Positive VEGF-C expression was in 27 specimens with 20 in lymph node metastasis. The expression of HMGB1 was consistent with VEGF-C expression, and HMGB1 and VEGF-C expressions were closely correlated with lymph node metastasis, but not with age, sex, cellular differentiation. Conclusion HMGB1 and VEGF-C expression may become predictor to the prognosis of colon cancer patients.

关 键 词：HMGB1 VEGF-C/D 淋巴道转移 结肠癌 

分 类 号：R73-37[医药卫生—肿瘤] R730.23[医药卫生—临床医学]