增殖细胞核抗原在子宫内膜病变组织中的表达及临床意义  

Expression of PCNA in endometrial diseases and clinical significance

作　　者：马晓欣[1] 孔令娜[1] 黄岭[1] 张淑兰[1] 

机构地区：[1]中国医科大学附属二院妇产科,辽宁沈阳110004

出　　处：《中华肿瘤防治杂志》2006年第9期656-658,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：辽宁省2002年博士启动基金(20021036)

摘　　要：目的:研究增殖细胞核抗原(PCNA)在子宫内膜病变中的表达规律及其在子宫内膜癌的发生、发展及估计患者预后中的临床价值。方法:用免疫组化SP法检测子宫内膜增殖症30例、非典型增生30例、子宫内膜癌90例,共150例作为实验组,分泌期及增生期内膜各30例作为对照组,观察PCNA在不同内膜病变及正常内膜中的阳性表达率。结果:PCNA在正常子宫内膜、子宫内膜增殖症、非典型增生阳性表达率依次呈升高趋势,子宫内膜增殖症与增生期内膜比较差异无统计学意义,P>0.05。而在非典型增生内膜和内膜癌组织中,PCNA表达明显增高,显著高于子宫内膜增殖症和增生期内膜,差异有统计学意义,P<0.01;且PCNA的阳性率与临床分期、细胞分化程度及淋巴转移有关。结论:PCNA与子宫内膜癌的发生和发展密切相关,PCNA表达对于子宫内膜癌的诊断和判断预后有重要意义。OBJECTIVE： To investigate the expression of proliferating cell nuclear antigen（PCNA） in endometrial diseases and its clinical significance for the incidence of endometrial carcinoma and predicting prognosis. METHODS：The experimental group included 150 eases ineluding 90 of endometrial carcinoma, 30 of edometrial hyperlpasia, 30 of atypical proliferation;the control group included 60 eases including 30 of proliferative endometrium and 30 of secretory endometriunx The expression of PCNA in these eases was deteded with the immunohistochemistry technology. RESULTS：There was a graduate increasing of the positive rate of PCNA expression in normal endometrium, endometrial hypwrplasia and atypical endometrium, and there was no statistical signifieanee between endometrial hyperplasia and proliferative endometritum,P〈0. 05. In endometrial carcinoma, the expression increased significantly, which is higher than benign diseases and control group prominently,P〈0. 01. Additionally, the positive rate of PCNA increased with the increasing of clinical phase and grade of cellular differentiation. CONCLUSlONS： PCNA is closely related to the development and the progression of endometrial carcinoma. The expression of PCNA is of great value in predicting the prognosis of endometrial carcinoma.

关 键 词：子宫疾病 子宫内膜/病理学 增殖细胞核抗原 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤] R711.74[医药卫生—临床医学]