COX-2和VEGF在食管鳞癌中的表达及其与淋巴结转移的关系  

Relationship between expressions of COX-2 and VEGF protein and lymph node metastasis in ESCC

作　　者：王丹云[1] 杨长征[2] 陈志涛[2] 张勃[2] 贾瑞[2] 

机构地区：[1]山东大学医学院病理教研室,山东济南250013 [2]济南市中心医院胸外科,山东济南250013

出　　处：《中华肿瘤防治杂志》2006年第9期689-691,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨血管内皮生长因子(VEGF)和环氧化酶-2(COX-2)蛋白在食管鳞癌(ESCC)中的表达情况及其与淋巴结转移的关系。方法:应用SP法对60例ESCC手术病理标本进行COX-2和VEGF蛋白表达检测。结果:COX-2和VEGF在ESCC中的表达率分别为85.0%(51/60)和53.3%(32/60)。有淋巴结转移组COX-2和VEGF的表达水平均高于未转移组。COX-2和VEGF蛋白的表达呈明显的正相关,r=0·5202,P<0·01。结论:ESCC中COX-2和VEGF的高表达与ESCC的发生、发展及淋巴结转移有重要关系。OBJECTIVE： To explore the relationship between high expressions of COX-2 and VEGF protein and lymph node metastasis in ESCC. METHODS： The immunohistochemistry method was applied to determine the expressions of COX-2 and VEGF in 60 surgically resected human esophageal cancer specimens. RESULTS： The positive rates of COX-2 and VEGF in ESCC were 85. 0% （51/60） and 53. 3%（32/60） respectively. The expression rates of COX-2 and VEGF were higher in the group of lymph node metastasis than those in the group without lymph node metastasis. COX-2 expression was significantly correlated with VEGF expression, r = 0. 520 2, P 〈 0. 01. CONCLUSIONS： The over-expressions of COX-2 and VEGF may play a crucial role in the carcinogenesis and development of ESCC, and it enhances lymphatic metastasis in patients with ESCC.

关 键 词：食管肿瘤 环氧化酶-2 血管内皮生长因子 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]