丹参对实验性急性乙醇胃粘膜损伤的保护作用及其机理的研究  

Protective effect of radix salvia miltiorrhiza on ethanol-induced acute gastricmucosal injury

作　　者：黄梅芳[1] 邓长生[1] 易季云[1] 林军[1] 周燕[1] 

机构地区：[1]湖北医科大学第二医院

出　　处：《中华消化杂志》1996年第2期82-84,共3页Chinese Journal of Digestion

摘　　要：采用无水乙醇制备急性胃粘膜损伤模型，观察丹参水溶液对急性胃粘膜损伤的影响。大鼠分为对照组、乙醇损伤组及丹参水溶液保护组。乙醇灌胃给人，保护组给予丹参水溶液后再给乙醇。结果表明：保护组与损伤组比较，胃壁结合粘液量、胃粘膜血流量增多，ＳＯＤ、ＧＳＨ－Ｐｘ活性增高，ＬＰＯ含量降低，胃粘膜损伤指数明显减低。认为丹参水溶液对乙醇急性胃粘膜损伤有保护作用，此与其增强胃粘膜防御功能、清除氧自由基及抑制脂质过氧化反应有关。Rat animal model of acute gastric mucosal injury was induced byintragastric ethanol instillation to study the protective effect of Radix SalviaMiltiorrhiza(RSM)on acute gastric mucosal injury.Rats were divided into threegroups,i.e, control group,gastric mucosal injury group by ethanol and RSM protectivegroup.RSM solution was given prior to ethanol instillation.The results indicate thatpretreatment with RSM can incrase the gastric mucus content and mucosal blood flow;reduce LPO content and increase SOD,GSH-Px activity,and significantly attenuatethe gastric mucosal injury.It is suggested that RSM has protective effect onethanol-induced gastric mucosal injury,and it might be due to improvement of gastricmucosal defence mechanism and its scavenging function of the oxygen free radicals.

关 键 词：胃粘膜损伤 乙醇 大鼠 丹参 药理学 

分 类 号：R573.105[医药卫生—消化系统] R286.56[医药卫生—内科学]