复方甘草酸苷对暴发性肝衰竭患者的保护作用  

Protective effect of Stronger Neo-Minophagen C on patients with fulminant liver failure

作　　者：于仲青[1] 杨宝山[1] 王岩[1] 陈立艳[1] 毕蔓茹[1] 王福祥[1] 马英骥[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院传染科,黑龙江省哈尔滨市150001

出　　处：《世界华人消化杂志》2006年第13期1318-1322,共5页World Chinese Journal of Digestology

基　　金：黑龙江省十五攻关重大课题;No.200101031-00~~

摘　　要：目的:探讨复方甘草酸苷(StrongerNeo-MinophagenC,SNMC)对暴发性肝衰竭(FLF)患者的保护作用.方法:全部病例均为2003-03/2005-03期间住院的患有急性、亚急性重型肝炎的86例实验分为治疗组和对照组.治疗组每天注射(iv)SNMC120mL,同时采用常规保肝支持对症治疗.对照组则仅用保肝支持对症治疗.对比观察两组的转氨酶(ALT)、胆固醇(CHOL)、总胆红素(TBIL)、凝血酶原活动度(PTA)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)、白介素-6(IL-6)的变化情况及病情转归.结果:ALT、TBIL两组比较差异不显著(P>0.05);CHOL、PTA在治疗组的恢复程度(3wk后)明显优于对照组,两组差异显著(P<0.01).两组治疗后,治疗组NO、IL-6水平与对照组相比有显著差异(24.5±18.1μmol/Lvs48.1±24.1μmol/L,P<0.01;76.9±71.2ng/Lvs357.1±79.1ng/L,P<0.01).治疗组有17例治疗无效,病死率为37.8%(17/45),对照组有29例治疗无效,病死率为70.7%(29/41),两组相比差异显著(P<0.01).结论:SNMC对暴发性肝衰竭有明显的保护作用,并抑制各种因素所介导的炎症反应,从而防止或缓解肝坏死及减少并发症,降低病死率.AIM： To discuss the protective effect of Stronger Neo-Minophagen C （SNMC） on patients with fulminant liver failure （FLF）. METHODS： From March 2003 to March 2005, 86 FLF patients were selected for this study, and they were assigned into group A and B. The patients in group A were intravenously injected with SNMC 120 mL per day, combined with symptomatic treatment to protect the liver. Symptomatic treatment was only performed on patients in group B, serving as controls. The level changes of serum alanine aminotransferase （ALT）, cholesterol （CHOL）, total bilirubin （TBIL）, prothrombin activity （PTA）, tumor necrosis factor TNF-α, nitrix oxide （NO）, and interleukin-6 （IL-6）, as well as the outcome of the disease, were observed and comparatively analyzed. RESULTS： The levels of ALT and TBIL had no significant difference between the two groups （P 〉 0.05）, while those of CHOL and PTA were significantly different between them （P 〈 0.01）. After treatment, the levels of NO and IL-6 were markedly lower in group A than those in group B （24.5 ± 18.1 μmol/L vs 48.1 ± 24.1 μmol/L, P 〈 0.01; 76.9 ± 71.2 ng/L vs 357.1 ± 79.1 ng/L, P 〈 0.01）. The fatality rates were 37.8% （17/45） and 70.7% （29/41）, respectively, in group A and B, and there was significant difference between them （P 〈 0.01）. CONCLUSION： SNMC has obvious protective effect on FLF patients through inhibiting the inflammation mediated by inflammatory mediators.

关 键 词：甘草酸苷 暴发性肝衰竭 炎症介质 病情转归 

分 类 号：R575.3[医药卫生—消化系统] R974[医药卫生—内科学]