(2β,3α,16β,17β)-3,17-双乙酰氧基-2,16-双哌啶基-5α-雄甾烷的合成  

Synthesis of(2β,3α,16β,17β)-3,17-diacetoxy-2,16-dipiperidino-5α-androstane

作　　者：赖朋[1] 马燕如[1] 赵肖玉[1] 徐正[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2006年第3期258-260,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的合成泮库溴铵和维库溴铵的中间体(2β,3α,16β,17β)-3,17-双乙酰氧基-2,16-双哌啶基-5α-雄甾烷。方法以表雄酮为原料,经磺酰化、消除、乙酰化、环氧化、取代、乙酰化反应合成目标化合物。结果所得产物及中间体经核磁共振谱确认。结论所设计合成路线可行,总收率30.4%,可用于工业生产。OBJECTIVE To synthesize intermediate of pancuronium bromide and vecuronium bromide, （2β,3α,16β,17β）-3,17- diacetoxy - 2,16 - dipiperidino - 5α - androstane. METHODS Target compound was synthesized by steps of tosylation, elimination, acylation, epoxidation, substitution and acylation. RESULTS Chemical structure of intermediate of Pancuwnium bromide and its intermediate were confirmed by ^1HNMR. CONCLUSION This synthetic method is feasible to industrialization. The total yield ratio of production is 30,4%.

关 键 词：雄甾烷类肌肉松弛药 泮库溴铵 维库溴铵 合成 

分 类 号：R914.5[医药卫生—药物化学]