α-亚麻酸对草酸钙结石大鼠尿纤溶活性影响的实验研究  

Experimental study on the α-Linolenic acid effect to the urinary fibrinolytic activity in calcium oxalate urolithiasis rats

作　　者：梁颖[1] 刘金宝[1] 王军[2] 叶章群[3] 宋波[2] 金锡御[2] 

机构地区：[1]新疆医科大学公共卫生学院营养与食品卫生学教研室,新疆乌鲁木齐830054 [2]第三军医大学西南医院全军泌尿外科,重庆400038 [3]华中科技大学同济医学院附属同济医院泌尿外科,湖北武汉430030

出　　处：《新疆医科大学学报》2006年第5期415-417,420,共4页Journal of Xinjiang Medical University

摘　　要：目的： 探讨尿纤溶活性在尿结石形成过程中的保护作用以及α-亚麻酸（α-LNA）对草酸钙结石鼠纤溶活性的影响.方法： 75只雄性Wistar成年大鼠随机分成5组,阴性对照组饲以普通饲料,阳性对照组饲以高脂饲料,成石组饲以高脂饲料加诱石剂饮水,苏子油组饲以高脂饲料加诱石剂饮水并每日苏子油灌胃（2 g/只）,葵花籽油组饲以高脂饲料加诱石剂饮水并每日葵花籽油灌胃（2 g/只）.实验8周后检测各组大鼠血清总胆固醇（TC）、甘油三酯（TG）、血纤溶酶原激活物（tPA）水平,并对各组进行比较.结果：苏子油组和葵花籽油组血清TC和TG水平显著低于阳性对照组（P〈0.05～0.01）,成石组tPA水平明显低于阴性对照组和苏子油组（P〈0.01）.结论： 尿纤溶活性是一种重要的抗结石形成而保护机体健康的因素,α-LNA可提高草酸钙结石鼠尿纤溶活性,抑制尿结石形成.Objective： To investigate the protective role of urinary fibrinolytic activity in urinary stone for mation and the effect of α-Linolenic acid on the fibrinolytic activity in calcium oxalate urolithiasis rats. Methods： The 75 male adult rats were random divided into five groups： negative control group rats were administered with common forage, positive control group rats were administered with high fat forage , stone group rats were administered with high fat diet and drinking 1% of ethylene glycol plus 1% of muri ate water, perilla frutescens （L · ） Britt · oil group rats were administered with high fat diet and drinking 1% of ehtylene glycol plus 1% of muriate water, meanwhil, tube feeding with perilla frutescens （L · ） Britt ·oil （10 g · kg^-1 · d^-1） and sunflower seeds oil group rats were administered with high fat diet and drinking 1% of ehtylene glycol plus 1% of muriate water, and tube feeding with sunflower seeds oil （10 g · kg ^-1· d ^-1）. 8 weeks later, serum cholesterol （TC）, the triglyceride （TG） and tissue type plasminogen activator（tPA） were detected and compared with. Results： Perilla frutescens （L ·） Britt · oil group and sunflower seeds oil group rats, the serum cholesterol and the triglyceride were signficantly lower than stone group （P 〈0.05-0.01）. Stone group tissue type plasminogen activator were significantly lower compared with negative control group and perilla frutescens （L · ） Britt · oil group （P 〈C0.01）. Conclusions： Urinary fibrinolytic activity was a important protective factor of urinary calculi formation, α-Linolenic acid may prevent calcium oxalate urolithiasis formation by increasing urinary fibrinolytic activity.

关 键 词：尿结石 尿纤溶活性 Α-亚麻酸 

分 类 号：R691.4[医药卫生—泌尿科学]