尾加压素Ⅱ生物学效应研究进展  

Progress in the study of biological activities of Urotensin Ⅱ

作　　者：竺晓鸣[1] 杜冠华[1] 

机构地区：[1]中国医学科学院.中国协和医科大学药物研究所国家药物筛选中心,北京100050

出　　处：《中国药理学通报》2006年第6期651-654,共4页Chinese Pharmacological Bulletin

基　　金：国家高技术研究发展计划(863计划)重大专项资金资助课题(No2004AA2Z3782)

摘　　要：尾加压素Ⅱ最初是从硬骨鱼中发现的环状多肽,是迄今为止发现的收缩血管活性最强的物质。尾加压素Ⅱ及其受体广泛分布于中枢神经系统和心血管系统中,并参与了许多疾病的病理发生过程。尾加压素Ⅱ在体内调节作用非常复杂,目前还缺乏对它全面的了解,大量研究资料表明尾加压素Ⅱ将可能成为很多疾病特别是心血管系统疾病治疗的又一个新靶点。Urotensin Ⅱ, found from the fish, is the a cycle peptide originally most potent vasoconstrictor. Urotensin Ⅱ and its receptor have been found in central nerve system, cardiovascular system and other organs and tissues. It has been suggested that urotensin Ⅱ plays important roles in the physiological and pathological procedures. Based on the evidences obtained from experiments, urotensin Ⅱ may become a new target for treating many diseases, particularly for cardiovascular diseases.

关 键 词：尾加压素Ⅱ 尾加压素Ⅱ受体 收缩血管 心肌重构 

分 类 号：R-05[医药卫生] R972.4