28例颈内动脉系统急性脑梗塞动脉溶栓治疗  

Intra-arterial thrombolysis in 28 patients with acute internal carotid circulation infarction

作　　者：练学淦[1] 段传志[1] 汪求精[1] 何旭英[1] 陈光忠[1] 尹家和[1] 李铁林[1] 

机构地区：[1]南方医科大学珠江医院神经医学研究所,广州510282

出　　处：《中华神经医学杂志》2006年第6期620-622,共3页Chinese Journal of Neuromedicine

摘　　要：目的分析颈内动脉系统急性脑梗塞动脉溶栓治疗的有效性和安全性。方法对28例颈内动脉急性脑梗塞的患者进行了动脉溶栓治疗,通过造影显示血管再通情况。术后即刻和24h后分别行头颅CT扫描以了解有无颅内出血(ICH)。术后第90天采用Barthel指数(BI)对患者生活状态进行评估。结果28例患者经动脉溶栓治疗,堵塞血管再通18例,部分再通6例,未通4例；症状性颅内出血8例,死亡5例。术后第90天,生活状态优者14例,良者8例,差或者死亡6例。再通患者生活状态明显优于部分再通及未通患者。结论动脉溶栓具有较高的症状性颅内出血率及死亡率。再通患者生活状态较好。Objective To evaluate the safety and efficacy of intra-arterial thrombolysis in patients with acute internal carotid circulation infarction. Methods Twenty-eight patients with acute internal carotid circulation infarction were treated with intra-arterial urokinase. Intracerebral hemorrhage （ICH） was investigated immediately and 24 h after the treatment by CT scanning. Barthel Index （BI） was used to evaluate the recovery of neurological functions 90 d after the treatment. Results Of the 28 patients, 18 achieved complete recanalization, 6 partial recanalization and 4 didn＇t get any recanalization. ICH was observed in 6 patients. 4 patients died. 90 d later, 14 patients had a good outcome, 8 a median outcome and 6 a poor outcome or died. The living status of patients with recanalization was significantly better than that of ones with partial recanalization and non-recanalization. Conclusion The rates of ICH and death following intra-arterial thrombolysis are high. The therapeutic outcome of recanalization is good.

关 键 词：动脉系统 血栓溶解疗法 脑梗塞 尿激酶 

分 类 号：R743.3[医药卫生—神经病学与精神病学]