花斑癣的遗传流行病学分析  

The genetic epidemiology of Tinea versicolor in China

作　　者：何素敏[1] 杜卫东[1] 杨森[1] 周顺铭[1] 李伟[1] 王剑[1] 徐生新[1] 张学军[1] 

机构地区：[1]安徽医科大学皮肤病研究所暨第一附属医院皮肤科,教育部重要遗传病基因资源利用重点实验室,安徽省基因研究重点实验室,合肥230022

出　　处：《安徽医科大学学报》2006年第3期298-301,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家863基金资助项目(编号:2003AA227030)

摘　　要：目的探讨花斑癣临床流行病学特征和可能的遗传模式。方法采用调查表的方式对503例花斑癣患者及其家系进行问卷调查，应用Epi6．0、SPSS10．0软件、Falconer公式和复合分离分析对资料进行统计学处理和分析。结果①503例花斑癣患者平均发病年龄（22．85±10．36）岁；男、女患者平均首发年龄分别为（23．45±10．51）岁和（21．53±9．91）岁（P〉0．05）；男女患者的首次发病高峰年龄均是20—29岁。②503例中有家族史者106例（21．1％），男性有家族史者发病年龄早于无家族史者（P〈0．01）；有家族史者复发频率较无家族史者高，病程也较长。③先证者一、二、三级亲属的发病率分别为5．31％、1．65％和0．28％；计算遗传度分别为48．13％、40．11％和27．20％。④通过复合分离分析，花斑癣的最佳遗传模型为多基因累加模式。结论遗传因素在发病过程中发挥重要作用。Objective To study the clinical and epidemiologic profile of pityriasis versicolor（PV） and to develop a possible genetic model for PV in Chinese Han. Methods Data for 503 patients with PV were obtained by questionnaire. Statistical analysis, heritability and complex segregation analysis were performed using EPI INFO 6. 0, SPSS10.0, the Falconer method, and the SAGE-REGTL programs. Results ① In total 503 PV patients, the mean age of onset was （22. 85 ± 10. 36） years. No statistically significant difference was found in the distributions of ages of onset between male （23.45 ± 10. 51 ） and female （21.5 ±9. 91 ） probands （P 〉0. 05）. For male and female patients, the peak ages of initial onset were both 20 -29 years. ② 106 （21.1%） patients were reported to have a family history of PV. The mean age of onset in males with family history was earlier than those without family history （ P 〈0. 01 ）. Higher rate of recurrence and longer duration were seen in the patients with family history than those without family history. ③ The prevalence of PV in first - , second - and third - degree relatives of the proband with PV was 5.31% , 1.65% and 0. 28% , respectively, which were higher correspondingly than those in controls. The heritability of PV in first-, second-and third-degree relatives was 48. 13%, 40. 11% and 27.20%, respectively. ④ Our findings on the genetics of PV were consistent with a pattern of muhifactorial inheritance according to Penrose＇ s method and REGTL results. Conclusion The effect of genetic factors is strong in PV. However, environmental factors such as infection, high temperature and humidity may still play important role.

关 键 词：花斑癣 流行病学 遗传度 

分 类 号：R756[医药卫生—皮肤病学与性病学]