Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution  

作　　者：Jesus K Yamamoto-Furusho Takeshi Takahashi-Monroy Omar Vergara-Fernandez Edgardo Reyes Luis Uscanga 

机构地区：[1]Departments of Gastroenterology. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City,Mexico [2]Departments of Surgery. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City,Mexico [3]Departments of Pathology. Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City,Mexico

出　　处：《World Journal of Gastroenterology》2006年第21期3406-3409,共4页世界胃肠病学杂志（英文版）

基　　金：Supported by the "Consejo Nacional de Ciencia y Tecnologia (CONACYT)", Mexico

摘　　要：AIM： To assess the prevalence and clinical value of p-ANCA in a sample of Mexican ulcerative colitis （UC） patients. METHODS： In a prospective, IRB-approved protocol, p-ANCA was determined in 80 patients with UC （mean age, 32 ± 12.9 years）. The severity and extension of disease were determined by clinical methods, searching a statistical association with p-ANCA status. RESULTS： p-ANCA were detected in 41 （51%） patients. Severity of disease was the only clinical variable statistically associated with their presence （P 〈 0.0001; OR = 9; CI 95% = 3.2-24.7）. CONCLUSION： The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.瞄准：在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-ANCA 的临床的价值病人。方法：在一个未来的、同意 IRB 的协议， p-ANCA 与 UC 在 80 个病人被决定(吝啬的年龄， 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定，寻找有 p-ANCA 地位的一个统计协会。结果：p-ANCA 在 41 被检测(51%) 病人。疾病的严厉是统计上与他们的存在联系的唯一的临床的变量(P < 0.0001；或 = 9；CI 95%= 3.2-24.7 ) 。结论：p-ANCA 的流行类似于在另外的国家报导了那。他们的存在被联系到 UC 严厉，但是比提供了没有更多的信息由临床的方法获得了。

关 键 词：Ulcerative colitis Inflammatory bowel disease Perinuclear anti-neutrophil cytoplasmic antibodies 

分 类 号：R574.62[医药卫生—消化系统]