VEGF-C的表达与食管鳞癌淋巴转移及预后的关系(英文)  

VEGF-C expression correlates with lymphatic metastasis and prognosis in esophageal squamous cell carcinoma

作　　者：逄小红[1] 田铧[2] 吕伯实[1] 葛兆茹[1] 李跃[1] 张凤鸣[1] 

机构地区：[1]泰山医学院解剖学教研室,山东泰安271000 [2]山东大学医学院解剖学教研室,山东济南250014

出　　处：《中国现代医学杂志》2006年第11期1606-1609,1613,共5页China Journal of Modern Medicine

基　　金：Sustentation fund:ThistaskwassuppliedbyShandongNaturalScienceFundItem(No.Y2000C12)

摘　　要：目的研究血管内皮生长因子(CVEGF-C)在食管鳞癌中的表达及其与肿瘤淋巴转移和预后的关系。方法运用免疫组化方法检测VEGF-C在72例食管鳞癌组织及其相应正常食管粘膜组织中的表达,经计算机图像分析,计算免疫组化阳性细胞百分率。结果正常食管粘膜中未见VEGF-C抗原的表达,而在72例食管鳞癌组织中有28例阳性表达(38.9%)。VEGF-C抗原表达与肿瘤的浸润深度和淋巴结转移密切相关(χ2=10.77,P<0.01;χ2=10.98,P<0.01),但与患者的年龄、肿瘤的大小及分化程度无关。VEGF-C阳性组患者的生存率显著低于VEGF-C阴性组(χ2=11.16,P<0.01)。结论VEGF-C的表达可促进食管鳞癌的淋巴转移。VEGF-C抗原可作为判断食管鳞癌不良预后的危险因子。[Objective] To investigate the expression of vascular endothelial growth factor-C （VEGF-C） in esophageal squamous cell carcinoma （ESCC）, and the relationship between its expression and the lymphatic metastasis and prognosis. [Methods] Immunohistochemical method was used to examine the expression of VEGF-C in 72 cases of the ESCC and adjacent normal esophageal mucosa, and the percentage of the cells positively stained with VEGF-C antibody was calculated with a computer-aided microscopic image analysis system. [Results] VEGF-C antigen was not expressed in normal esophageal mucosa but detected in 28 of 72 （38.9%） neoplastic esophageal lesions. The expression of VEGF-C antigen was significantly associated with the depth of tumor invasion （X^2=10.77, P 〈0.01） and lymph node metastasis（x^2=10.98, P 〈0.01）, but not with the patients＇ age, tumor size or differentiation （P 〉0.05）. The overall survival rate of the patients with positive VEGF-C expression was significantly lower than that of the patients without VEGF-C expression （ X^2=11.16, P 〈0.01）. [Conclusion] The expression of VEGF-C in ESCC can promote tumor lymphatic metastasis, and it may serve as a risk factor indicating a poor prognosis of ESCC.

关 键 词：食管肿瘤 血管内皮生长因子C 淋巴转移 预后 

分 类 号：R737.1[医药卫生—肿瘤]