胶原蛋白多肽-铬(Ⅲ)螯合物的降血糖机理探讨  

STUDY ON THE HYPOGLYCEMIC EFFECTS OF COLLAGEN PEPTIDE-CHROMIUM(Ⅲ) COMPLEX

作　　者：王秀丽[1] 刘安军[1] 李琨[1] 高伟佳[1] 刘景彬[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300222

出　　处：《食品研究与开发》2006年第5期125-126,48,共3页Food Research and Development

基　　金：天津市自然科学基金项目(No.013617111)

摘　　要：观察胶原蛋白多肽-铬(Ⅲ)螯合物的降血糖作用,探讨它降血糖的可能机理。通过腹腔注射四氧嘧啶造小鼠糖尿病模型,观察血糖、肝糖原、葡萄糖激酶等指标。胶原蛋白多肽-铬(Ⅲ)螯合物可以显著地降低血糖,增加肝糖原的合成及葡萄糖激酶的活性。胶原蛋白多肽-铬(Ⅲ)螯合物可降低糖尿病小鼠血糖,促进肝糖原的合成和糖尿病小鼠体内的葡萄糖磷酸化。To observe the hypoglycemic effects of Collagen Peptide-Chromium（Ⅲ ） Complex（CPCC）, and its action mechanism is also preliminary explored. An experimental diabetes model was produced by intraperitoneal injection of alloxan. Blood glucose, liver glucokinase and liver glycogen contents were measured. CPCC could markedly decrease blood glucose, increase liver glycogen contents and improve liver glucokinase activity.CPCC has dramatic hypoglycemic activity, it can promote liver glycogen synthesization and improve the liver glucokinase activity.

关 键 词：胶原蛋白多肽-铬(Ⅲ)螯合物 糖尿病 肝糖原 葡萄糖激酶 

分 类 号：TS201.2[轻工技术与工程—食品科学]