精神分裂症患者口咽部定植菌谱和耐药性的研究  

Explore the bacterial spectrum and drug ressitance in the respiratory tract in schizophrene

作　　者：刘洪光[1] 金冬[1] 刘雪琴[1] 王元彬[1] 吴怀安[1] 

机构地区：[1]深圳市康宁医院检验科,广东省深圳518020

出　　处：《中国基层医药》2006年第5期821-822,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市科技局立项课题(200405052)

摘　　要：目的研究住院精神分裂症患者口咽部病原菌的定植和耐药情况。方法对311份住院精神分裂症患者的咽拭子进行细菌培养和药敏试验并对结果进行统计分析。结果共分离出59株病原菌,其中G-菌占55.93%,G+占44.07%;克雷伯菌、金黄色葡萄球菌、大肠埃希菌、乙型溶血性链球菌、肠球菌居分离菌前5位,分别占35.6%、27.1%、13.6%、8.5%、5.1%;G+球菌(除部分肠球菌外)对万古霉素仍保持100%敏感,G-杆菌对亚胺培南、阿米卡星保持较高敏感率外,其他抗生素耐药率均呈上升趋势。结论住院精神分裂症患者口咽部定植菌以肠杆菌科和金黄色葡萄球菌等外源性细菌定植为主且耐药情况严重,临床应根据药敏结果合理选用抗生素以减少或延缓耐药菌的出现。Objective To explore the bacterial spectrum and drug resistance that separated from respiratory tract of sehizophrene. Methods 311 samples taken from the respiratory tract of sehizophrenes were investigated and analyzed. Results From 311 samples 58 pathogenic bacteria were separated, the gram negative was 55.93 % and the gram positives was 44.07 % ; 5 most pathogenic eommoly bacteria were ldesbsiella pneumoniae and S. aureus and escheriehia eoli and streptococcus and enteroeoeeus;Except that all the staphylococcus were sensitive to vaneomyein, enterobaeteriaeeae were sensitive to imipenem, all the other separated strains showed total resistance to the agents tested in different levels,also the multidrug resistance emerged in lower respiratory tract infections with mulitidrug resistance in high levels. Conclusion The most common pathogenic bacteria separated from these schizophrene are klesbaiella pneumoniae and S. aureus. In clinical therapy,sensitive antibiotics should be selected according to the drug sensitive tests, combine with other agents when necessary to accelerate the clearance of bacteria from infectious respi- ratory tract in sehizophrene.

关 键 词：精神分裂症 口咽 细菌学 微生物敏感性试验 

分 类 号：R749.3[医药卫生—神经病学与精神病学]