昆虫乙酰胆碱酯酶基因研究进展  

Advances in the studies of acetylcholinesterase genes from insects

作　　者：王敦[1] 唐振华[2] 尚金燕[1] 张传溪[1] 

机构地区：[1]浙江大学应用昆虫学研究所,杭州310029 [2]中国科学院上海植物生理生态研究所,上海200032

出　　处：《昆虫学报》2006年第3期497-503,共7页Acta Entomologica Sinica

基　　金：国家重点基础研究发展规划"973"计划(2003CB114403);国家自然科学基金重点项目(30230070)

摘　　要：对昆虫乙酰胆碱酯酶(acetylcholinesterase,AChE,EC3·1·1·7)的基因结构和表达等方面的研究进展进行了综述。分析了昆虫乙酰胆碱酯酶基因的结构,包括10个外显子的特征。对已经报道的昆虫AChE基因进行了系统归纳,并基于已知全序列的昆虫AChE基因,进行了昆虫AChE基因的分子进化分析。对昆虫AChE基因的结构特点及其功能,以及昆虫AChE基因的活性位点、AChE的变构与昆虫抗药性的关系进行了探讨。最后对昆虫AChE基因研究中存在的问题和前景进行了分析和展望。Recent advances in the studies of acetylcholinesterase （ACHE, EC 3.1.1.7） genes from insects were reviewed. The gene structure, including ten extrons of insect AChE gene （ ace）, was discussed. All the ace genes reported from insects were summed up, and the phylogenetic tree was constructed based on the reported complete sequences of ace genes from insects. The ace structure characteristics, the functional sites of ace genes, the effect of ace mutation （s） on insecticide resistance and their relationships were also discussed. Finally, the problems and prospects in the studies of insect ace were analyzed.

关 键 词：乙酰胆碱酯酶 乙酰胆碱酯酶基因 分子进化 基因突变 抗药性 

分 类 号：Q966[生物学—昆虫学]