精神分裂症与G72基因多态性的关联分析  

An analysis of association between schizophrenia and G72 gene polymorphism

作　　者：方贻儒[1] 洪武[1] 汪作为[1] 汪栋祥[2] 江三多[2] 王祖承[1] 

机构地区：[1]上海交通大学医学院精神医学教研室,上海第二医科大学精神医学教研室,200025 [2]上海市精神卫生中心

出　　处：《临床精神医学杂志》2006年第3期129-131,共3页Journal of Clinical Psychiatry

基　　金：国家自然科学基金资助项目(30270494)

摘　　要：目的:探讨精神分裂症与G72基因多态性的关系,是否有混合家族史精神分裂症在G72基因多态性的区别。方法:采用聚合酶链反应技术分别检测162例无混合家族史精神分裂症、62例有混合家族史精神分裂症、88名正常对照的G72基因单核苷酸多态性rs947267、rs2181953,进行关联分析。结果:不同性别及发病年龄的无混合家族史精神分裂症组与对照组rs947267、rs2181953基因型及等位基因分布差异均无显著性(P均>0.05);不同性别及发病年龄的有混合家族史精神分裂症组与对照组rs947267基因型及等位基因分布差异无显著性(P>0.05);不同性别及早发型(发病年龄≤25岁)有混合家族史精神分裂症组与对照组rs2181953基因型及等位基因分布差异无显著性(P>0.05);晚发型(发病年龄>25岁)有混合家族史精神分裂症与对照组rs2181953基因型及等位基因分布差异显著(χ2=9.121,P=0.01与χ2=6.804,P=0.01),基因型A/A、T/T及等位基因A、T的OR值分别为7.083(P=0.007)、0.357(P=0.049)、2.531(P=0.009)、0.395(P=0.009)。结论:G72基因多态性可能与晚发型有混合家族史精神分裂症存在关联,其中rs2181953的A/A基因型与A等位基因是危险因子。Objective：To investigate the association between SNPs of G72 gene and schizophrenia, and to probe the difference in G72 gene polymorphism between schizophrenia with and without mixed disorder relatives. Method： 162 schizophrenic patients without mixed disorder relatives, 61 schizophrenic patients with mixed disorder relatives and 88 normal controls were involved in the study. Polymorphism of rs947267 and rs2181953 of G72 gene were determined with polymerase chain reaction and the associations were analyzed. Results： No significant differences were found in the frequencies of rs947267 and rs2181953 genotypes and alleles between different gender and onset age schizophrenic patients without mixed disorder relatives and normal controls （ P 〉 0.05） and in the frequencies of rs947267 genotypes and alleles between schizophrenic patients with mixed disorder relatives and controls （ P 〉 0.05）. There were also no significant differences in the frequencies of rs2181953 genotypes and alleles between schizophrenic patients （first suffering age ≤25） with mixed disorder relatives and the controls （ P 〉 0.05）. However, the frequencies of rs2181953 genotypes and alleles in the schizophrenic patients （first suffering age 〉 25 ） with mixed disorder relatives were significantly different with the controls group （ P 〈 0.05）, and the OR scores were respectively 7. 083（A/A genotype, P = 0.007）,0.357（T/Tgenotype,P=0.049）,2.531（A allele, P=0.009） and0.395（ Tallele, P=0.009）. Condusion：The G72 gene polymorphism may be associated with schizophrenia with mixed disorder relatives, A/A genotype and A allele of rs2181953 might be the risk factors.

关 键 词：精神分裂症 混合家族史 G72基因 

分 类 号：R749.3[医药卫生—神经病学与精神病学]