伽玛刀治疗难治性强迫症临床研究  

Study of refractory obsesive-compulsive disorder treated with Gamma knife

作　　者：谢世平[1] 佘永传[1] 常义[1] 张心保[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029

出　　处：《临床精神医学杂志》2006年第3期137-138,共2页Journal of Clinical Psychiatry

基　　金：江苏省教育厅基金资助(02KJB320006);南京市卫生局基金资助(ZKG0007)

摘　　要：目的:探讨伽玛刀治疗难治性强迫症的疗效和安全性。方法:选择12例门诊或住院难治性强迫症患者,使用伽玛刀毁损内囊前肢进行治疗。于手术前、手术后1个月、3个月、6个月、1年、2年、3年评定耶鲁-布朗强迫症量表(Y-BOCS)、社会功能缺陷筛选量表(SDSS)。结果:伽玛刀手术后3个月开始起效,Y-BOCS评分显著降低,1年疗效达高峰。总有效率为91.7%(11/12),其中7例痊愈,3例显著进步,1例进步,1例无效。经3年随访,未发现严重不良反应,仅1例出现人格改变。结论:伽玛刀是目前治疗难治性强迫症的一种安全有效的方法。Objective： To detect the effect and safety in treatment of refractory obsessive-compulsive disorder （OCD） with Ganrna knife. Method： 12 inpatients or outpatients with refractory OCD were ruined at anterior limb of internal capsules by Gamma knife. Yale-Brown obsessive compulsive scale（Y-BOCS） and social disability screening schedule（SDSS） were evaluated before operation and at I mouth, 3 months,6 months, 1 year,2 years,3 years after operation. Results： It showed respense in 3 mouths after operation. Y- BOCS score was significantly lower than that of before operation and got peak of effect in one year. Total rate of effect was 91.7 % （11/12）,7 cases recovery, 3 cases apparent advance, 1 case advance, and 1 case no response. There was no severe side effect during 3 years follow-up except for I ease appearing personality change. Conclusion：Gamma knife is one of safety and effect methods to treat refractory OCD at the moment.

关 键 词：伽玛刀 难治性强迫症 

分 类 号：R749.7[医药卫生—神经病学与精神病学]