组织型纤溶酶原激活物与血栓相关性疾病的关系研究  

The Study of Relationship between Tissue Plasminogen Activator and Diseases Related to Thrombus

作　　者：于淑红[1] 王鸿玲[1] 邢美玲[1] 

机构地区：[1]烟台毓璜顶医院输血科,山东烟台264000

出　　处：《医学综述》2006年第12期732-734,共3页Medical Recapitulate

摘　　要：血栓性疾病的及时、准确诊断及溶栓治疗效果,对疾病的预后起着关键作用。组织型纤溶酶原激活物(t PA)活性异常是心血管疾病血栓前状态的最危险因素。因此,密切观察t PA等纤溶能力指标的变化,对判断血栓相关性疾病的形成和发展有着十分重要的意义。目前检测t PA的方法主要为ELISA法测抗原及发色底物法测活性,这两种方法均有其局限性。The prompt and corret diagnosis of thrombotic disease and therapentic effecacy of thrombolysis play a key role in the prognosis of diseases. The abnormal activity of tissue-type plasminogen activator（t-PA） is the most risk factor of prethromhotic state of cardiorascalar diseases. So it has an important significance to observe closely the index of fibrinolysis ability in order to judge the formation and development of diseases related to thrombus Now, there are two main methods to detect t-PA,one is ELISAto detece the t-PA antigen,the other is luminescence substrate assay to detect t-PA activity. But the two methods sill have their limitation.

关 键 词：组织型纤溶酶原激活物 血栓相关性疾病 逆转录聚合酶链反应 血栓前状态 

分 类 号：R364.1[医药卫生—病理学]