大脑对早期、晚期冲突信息处理的事件相关电位研究  

Conflict information monitored and processed in human brain

作　　者：董艳娟[1] 王玉平[2] 王荫华[3] 毛薇[2] 

机构地区：[1]北京军区总医院干部病房三科,北京100700 [2]首都医科大学宣武医院神经内科 [3]北京大学第一医院神经科

出　　处：《临床神经电生理学杂志》2006年第3期136-141,共6页Journal of Clinical Electroneurophysiology

摘　　要：目的:进一步了解大脑处理冲突信息的机制。方法:采用脑事件相关电位(ERP)技术, 用经典的Flanker作业刺激范式组成的成对刺激作为视觉刺激,并通过低分辨率电磁地形图(LORETA) 技术,对16例健康正常受试者进行测检。结果:无论是失匹配状态、不一致Flanker作业,还是二者兼而有之,均可引出一负波。该冲突性负波主要分布在前、中头部。LORETA源定位分析显示该负波可能源于前额叶皮层、扣带回。结论:大脑存在一个探测及处理冲突信息的系统。该系统处理各种冲突信息,可能位于前额叶皮层、扣带回附近。Objective：To investigate the mechanism of monitoring and processing conflict in human brain. Methods：The event related potential （ERP） was determined in 16 subjects. Flanker task in a visual S1- S2 matching paradigm was used to examine event-related potentials. ERPs were recorded respectively in the above-mentioned conditions, while subjects were engaged in a visual discrimination task by pressing specified key. Results：The negativity was elicited by the incompatible Flanker stimulus as well as by the mismatch stimulus. The negativity distributed maximally over the fronto-central site. The map of low resolution electromagnetic tomography （LORETA） for the conflict negativity suggests that the medial frontal cortex,especially anterior cingulate cortex, may be involved in conflict detection and resolution. Conclusions：The conflict of mismatch （early conflict） as well as Flanker （late conflict） can both evoke negativity, and further confirm that the negativity does relate to the detecting and processing of various kinds of cgnflict either from the perception level or the decision-making level. A conflict detecting and processing system exists in human brain, which may be located in medial frontal cortex and anterior cingulate cortex.

关 键 词：Flanker作业 N270 冲突相关性负波 失匹配 冲突监测及处理 

分 类 号：R741.044[医药卫生—神经病学与精神病学] R322.81[医药卫生—临床医学]