超声造影在评价高强度聚焦超声治疗肿瘤疗效中的作用  

The Value of Contrast-enhanced Ultrasound in Evaluating Therapeutic Response with High Intensity Focused Ultrasound for Tumor

作　　者：陈建科[1] 张闻[1] 刘学明[1] 胡晓晔[1] 许俊[1] 莫国强[1] 洪玉蓉[1] 

机构地区：[1]浙江大学医学院附属第二医院,浙江杭州310009

出　　处：《肿瘤学杂志》2006年第3期191-193,共3页Journal of Chinese Oncology

基　　金：浙江省科技厅(2005C33001)

摘　　要：[目的]了解超声造影在高强度聚焦超声(HIFU)治疗肿瘤临床疗效评价中的应用价值。[方法]选取高强度聚焦超声治疗的肿瘤患者42例(60个病灶)为观察对象。59个病灶HIFU治疗前后采用超声造影检查评价疗效,其中18例患者(23个病灶)与增强CT检查结果进行比较。[结果]HIFU治疗前,超声造影观察60个病灶,51个病灶表现为动脉期增强,8个病灶表现为静脉期增强,治疗后行超声造影检查,显示27个病灶各期均无异常增强区,提示肿瘤“完全灭活”;23个病灶治疗后边缘局部有增强,提示有肿瘤残存;9个病灶呈地图样充盈缺损,提示肿瘤大部分没有灭活。18例患者(23个病灶)超声造影结果与增强CT检查结果相近。[结论]超声造影是评价HIFU的一种有效方法,且能明确肿瘤残存部位引导补充治疗,有助于评价治疗后肿瘤灭活范围。[Purpose] To investigate the role of contrast-enhanced ultrasound in evaluating therapeutic res ponse with high intensity focused uhrasound（HIFU） for tumor. [Method] Forty-two patients（60 lesions） were enrolled in this study. Fifty-nine lesions were examined with contrast-enhanced ultrasound before HIFU treatment and after HIFU treatment. The results of 18 patients （23 lesions ）were compared with enhanced CT. [ Results ] Fifty-one of 60 lesions showed enhancement during arterial phase and 8 lesions showed enhancement during venous phase with contrast-enhanced ultrasound before HIFU treatment. Twenty-seven of 59 lesions after HIFU treatment showed no enhancement with contrast-enhanced ultrasound indicating complete necrosis; 23 lesions which showed marginal local enhancement were diagnosed as tumor residual; and 9 lesions which showed intralesional heterogeneous hypo-enhancing like map indicating a little necrosis. And the result of 18 patients （23 lesions） with contrast-enhanced ultrasound was similar to enhanced CT. [Conclusion] Contrast-enhanced uhrasound can help to assess the therapeutic response of HIFU and indicate the position of residual tumor during the additional treatment.

关 键 词：超声检查 造影剂 高强度聚焦超声 肿瘤 

分 类 号：R730.41[医药卫生—肿瘤]