紫杉醇联合5-氟尿嘧啶和顺铂治疗晚期胃癌58例  

Paclitaxel Combined with 5-fluorouracil and Cisplatin in the Treatment of 58 Cases with Advanced Gastric Cancer

作　　者：应杰儿[1] 钟海均[1] 董勇[1] 

机构地区：[1]浙江省肿瘤医院,浙江杭州310022

出　　处：《肿瘤学杂志》2006年第3期217-219,共3页Journal of Chinese Oncology

摘　　要：[目的]观察紫杉醇联合5-氟尿嘧啶及顺铂(PCF方案)治疗晚期胃癌的临床疗效和毒副反应。[方法]晚期胃癌患者58例,给予紫杉醇(PTX)150mg/m2,静滴3h,d1;5-氟尿嘧啶(5-Fu)500mg/m2,d1～5或750mg/m2,d1～3;顺铂(DDP)15mg/m2,d1～5或30mg/m2,d1～3;21～28d为1个周期。至少2个周期后按RESCIST标准评价疗效和毒副反应。[结果]全组57例可评价疗效,初治组35例,无完全缓解病例,部分缓解15例,稳定17例,进展3例,近期客观有效率42.9%,中位达进展时间(TTP)为6.0个月。复治组22例,无完全缓解病例,部分缓解3例,稳定16例,进展3例,近期客观有效率13.6%,中位TTP为3.2个月。主要毒副反应为骨髓抑制、恶心呕吐和脱发。[结论]PCF方案治疗晚期胃癌近期疗效确切,毒副反应可以耐受,初治患者效果更佳。[Purpose] To evaluate the efficacy and toxicity of paclitaxel （PTX） combined with 5-fluorouracil （5-Fu） and cisplatin （DDP） regimen （PCF regimen） in patients with advanced gastric cancer. [Methods] Fifty-eight cases with advanced gastric cancer were treated with PCF regimen： 150mg/m^2 3h d1, 5-Fu 500mg/m^2 d1-5 or 750mg/m^2 d1-3, DDP 15mg/m^2 d1-5 or 30mg/m^2 d1-3 every 21-28 days. Response and toxicity were evaluated according to RESCIST standard after 2 courses. [Results] Fifty-seven cases were available for response evaluation. In the initial treatment group the response rate was 42.9% with CR, 0; PR,15; SD,17;PD,3; and the time to tumor progression （TTP） was 6.0 months.In the retreatment group the response rate was 13.6% with CR,0; PR,3; SD,16; PD,3; and the TTP was 3.2 months. The main toxicities were bone marrow suppression, nausea /vomiting and alopecia. [Conelusion]PCF regimen has an assured response for advanced gastric cancer with tolerable toxicity, especiallv for initial treatment.

关 键 词：胃肿瘤 紫杉醇 氟尿嘧啶 顺铂 药物疗法 

分 类 号：R735.2[医药卫生—肿瘤]