35例局部晚期胃癌EOLF方案新辅助化疗临床观察  

Neoadjuvant Chemotherapy with EOLF Regimen for 35 Cases with Locally Advanced Gastric Cancer

作　　者：王建芳[1] 田景琦[1] 吕杰青[1] 

机构地区：[1]绍兴市人民医院,浙江绍兴312000

出　　处：《肿瘤学杂志》2006年第3期220-221,共2页Journal of Chinese Oncology

摘　　要：[目的]探讨局部晚期胃癌新辅助化疗的治疗效果。[方法]35例局部晚期胃癌采用EOLF方案(CF+5-Fu+LOHP+E-ADM)术前化疗,1～2个周期后重新分期、评价疗效并手术。[结果]35例患者中,无临床完全缓解病例,部分缓解(PR)19例,稳定(SD)9例和进展(PD)7例;临床降期19例,化疗后手术切除率达91.3%。[结论]新辅助化疗可以降低部分局部晚期胃癌的临床分期,提高手术切除率。[Purpose] To evaluate the efficacy of neoadjuvant chemotherapy for the patients with locally advanced gastric cancer. [Methods] Preoperative chemotherapy with EOLF regimen（CF＋5-Fu＋LOHP＋E-ADM） was performed in 35 cases with locally advanced gastric cancer. Restaging, response assessment, and surgery were carried out after 1-2 courses. [Results] Of 35 cases 0 with CR, 19 with PR, 9 with SD and 7 with PD were achieved. Cancer resection rate was 91.3% following neoadjuvant chemotherapy. [Conclusions ] Neoadjuvant chemotherapy may improve staging and cancer resectability for locally advance gastric cancer.

关 键 词：胃肿癌 新辅助化疗 疗效 

分 类 号：R735.2[医药卫生—肿瘤]