人宫颈癌组织中肝素酶蛋白的表达  

The expression of heparanase in the human cervical cancer's tissue

作　　者：侯箐岚 党群[1] 李玉华[1] 单中杰[1] 

机构地区：[1]河南省郑州市第五人民医院妇产科,郑州450003

出　　处：《中原医刊》2006年第12期17-18,共2页Central Plains Medical Journal

摘　　要：目的探讨肝素酶蛋白表达与宫颈癌发生发展的关系。方法采用免疫组织化学SP法检测58例正常宫颈上皮、宫颈上皮内瘤样变(C IN)及宫颈鳞癌组织中肝素酶的蛋白表达。结果58例正常宫颈上皮、C IN及宫颈鳞癌组织中肝素酶蛋白的阳性表达率分别为:7.14%(1/14)、33.33%(6/18)及84.62%(22/26),三者两两相比差异有统计学意义(P<0.05)。结论肝素酶蛋白表达与宫颈癌发生发展相关,肝素酶指标可能在宫颈癌的早期筛查、诊断、治疗及预后判断中具有一定意义。Objective To study the expression of heparanase in the pathogenesis and development of human cervical cancer. Methods Immunohistochemieal SP methods was used to detect the expression of heparanase protein in 58 cases of normal cervical epithelium,cervical intraepithelial neoplasm（CIN） and cervicals quamous cell carcinoma. Results The positive rates of expression of heparanase protein in 58 eases of normal cervical epithelium,cervical intraepithelial neoplasm （CIN） and eervicals quamous cell carcinoma were 7.14% （1/14）, 33.33%（6/18） and 84.62% （22/26）,respectively. There were significant differences among the three groups （ P〈0.05）. Conclusion The expression of heparanase protein may be involved in the pathogenesis and development of cervical cancer. It may be used as marker in the diagnosis,treatment and prognostic evaluation.

关 键 词：肝素酶 宫颈癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]