哌啶酮衍生物的合成工艺改进  

Improved synthesis of piperidone derivatives

作　　者：魏文涛[1] 李祎亮[1] 周学福[1] 

机构地区：[1]天津泰普药品科技发展有限公司,天津300193

出　　处：《中国药物化学杂志》2006年第3期180-181,共2页Chinese Journal of Medicinal Chemistry

摘　　要：以甲胺、丙烯酸甲酯和甲基丙烯酸甲酯为起始原料,依次经过加成、狄克曼缩合及水解脱羧反应,简捷、高效地合成4-哌啶酮衍生物,通过对缩合剂、溶剂、反应温度等工艺条件进行考察,探索出稳定的合成工艺路线。该工艺路线降低了成本,减少了环境污染,增加了生产的安全性,适合工业化生产。4-Piperidone was synthesized via 1, 4-addition, Dieckmann condensation, hydrolysis and decarboxylation. The conditions of catalyst, solvent and temperature etc., were studied to establish the stabilization technology to prepare 4-piperidone derivative. This process saves the costs of material, reduces the pollution of surroundings, and increases the safety factor in industrialized produce.

关 键 词：药物化学 工艺改进 化学合成 哌啶酮衍生物 Dieckmann缩合 

分 类 号：TQ463[化学工程—制药化工]