皮肤基底细胞癌、鳞状细胞癌表皮生长因子及其受体免疫组化研究  

IMMUNOHISTOCHEMICAL STUDY ON EGF AND EGFR IN BASAL CELL CARCINOMASAND SQUAMOUS CELL CARCINOMAS OF SKIN

作　　者：刘宝军[1] 张海涛[1] 李淑琴[1] 陈伟[1] 李润江[1] 

机构地区：[1]沈阳军区总医院

出　　处：《解放军医学杂志》1996年第2期105-106,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：应用免疫组化法观察了４３例基底细胞癌（ＢＣＣ）、２６例鳞状细胞癌（ＳＣＣ）表皮生长因子（ＥＧＦ）及其受体（ＥＧＦＲ）的表达。结果表明：ＥＧＦ及ＥＧＦＲ在所有ＢＣＣ中表达均有增强，且在边缘肿瘤组织表达强于中央肿瘤组织。ＳＣＣ组织中ＥＧＦ及ＥＧＦＲ表达强度与肿瘤分化程度呈负相关。提示ＥＧＦ和ＥＧＦＲ对ＢＣＣ及Ｓｃｃ的发展可能起促进作用；ＳＣＣ组织中ＥＧＦ及ＥＧＦＲ表达有助于识别其生物学行为及估计预后。Expressions of EGF and EGFR were observed by immunohistochemistry in 43 cases of basal cellcarcinoma(BCC),and in 26 cases of squamous cell carcinoma(SCC).The results showed that:(1)Increased ex-pressions of EGF and EGFR were seen in all BCC,the expressions of EGF and EGFR in the peritumors weregreater than those in the central areas of the tumor.(2)An apparent negative relationship was found between tu-mor differentiation and the expressions of EGF and EGFR in SCC,It is suggested that EGF and EGFR may playa role in the development of BCC and SCC,the pattern of the expressions of EGF and EGFR in BCC and SCCmay be helpful in distinguishing their biological behaviors and in predicting their prognosis.

关 键 词：皮肤肿瘤 基底细胞癌 鳞状细胞癌 表皮生长因子 

分 类 号：R739.503[医药卫生—肿瘤]