p21活化激酶的生物学活性及其与肿瘤的关系  

The Biological Characteristics of p21-activated Kinase and Its Contribution to Cancer

作　　者：李晓东[1] 李彦姝[1] 赵大林[2] 李丰[1] 

机构地区：[1]中国医科大学细胞生物学卫生部重点实验室,沈阳110001 [2]沈阳体育学院,生理学教研室,沈阳110032

出　　处：《细胞生物学杂志》2006年第3期399-404,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30370736;No.30570966);教育部博士点基金(No.20050159023);教育部回国人员科研启动基金资助~~

摘　　要：p21活化激酶(p21-activatedkinase,PAK),为一类进化上保守的丝氨酸/苏氨酸蛋白激酶。PAK在许多组织中广泛表达,作为小G蛋白Rho家族Cdc42和Rac1的下游靶蛋白,可以被生长因子及其他胞外信号通过GTP酶依赖的信号通路或非GTP酶依赖的信号通路活化,发挥多种生物学效应。PAK作为一种重要的生物学调节因子,在哺乳动物一系列细胞功能中具有重要作用,如:细胞运动、细胞生存、细胞周期、血管生成、基因转录调节及癌细胞的侵袭转移。通过对PAK家族成员信号转导机制的研究,为癌症治疗提供分子靶标。The p21-activated kinases （PAKs）, an evolutionarily conserved family of serine/threonine kinases, are expressed in many tissues, As target of the small GTPase of Rho family, PAK can be regulated by many growth factors through GTP-dependent and GTP-independent way. PAKs are important for a variety of cellular functions including cell motility, survival, cell cycle, gene regulation and angiogenesis, especially in tumor invasion and metastasis, In this review, we summarized the current knowledge of PAK with respect to emerging cellular functions and possible contribution to cancer.

关 键 词：P21活化激酶 肿瘤 信号转导 

分 类 号：R730.2[医药卫生—肿瘤]