自体子宫移植建立子宫内膜异位症大鼠模型  

Establishment of Endometriosis Model in Rats with Intact Uterine Tissues

作　　者：曾如辉[1] 罗丽莉[1] 许铭炎[2] 徐晓园[2] 史咏梅[2] 隋旭霞[2] 傅玉才[2] 

机构地区：[1]汕头大学医学院第一附属医院妇科,汕头515031 [2]汕头大学医学院细胞衰老实验室,汕头515031

出　　处：《实验动物与比较医学》2006年第2期72-74,127,共4页Laboratory Animal and Comparative Medicine

基　　金：广东省科技计划资助项目(2003C34413);广东省自然科学基金资助项目(5008360);广东省中医药局资助项目(1050135)

摘　　要：目的构建子宫内膜异位症(内异症)大鼠动物模型。方法取性成熟雌性SD大鼠26只,手术将大鼠自体子宫组织移植到子宫旁韧带上,建立诱发型内异症大鼠动物模型。术后8周,再次剖腹观察异位组织的存活情况、病灶大小、与周围组织的粘连程度以及病理学变化。结果21只大鼠有明显的异位病灶。所有病灶都与周围组织有不同程度的粘连,病灶外观呈囊泡状。光镜观察见大部分异位子宫内膜形态和结构与在位子宫内膜基本相同,但内膜细胞、间质细胞、腺体,与在位内膜相比较少。少数病灶只有上皮组织或只有间质组织。结论自体子宫移植法可成功建立内异症大鼠模型。Objective To establish the endometriosis models in rats. Methods Twenty-six mature female SD rats were used. The rat endometriosis model was established by autotransplantation with uterine tissues. Eight weeks after the autotransplantation,the second laparotomy was performed for observing the size,conglutination and pathological changes of the autotransplants. Results Saccate autotransplants were found in twenty-one rats, all of which were embedded in the peripheral tissues. The morphology and structure of most ectopic endometrium were as same as the eutopic endometrium, though there were less epithelium and stroma in ectopic tissues. However, in a few cases, there was either epithelium or stroma. Conclusion The endometriosis model established is successful, which can provide an ideal model for further study of the mechanism and medical treatment of endometriosis.

关 键 词：子宫内膜异位症 疾病模型 动物 大鼠 

分 类 号：R-332[医药卫生]