肝再生的调控及原癌基因表达  

Control of Growth and Expression of Protooncogenes in Regenerating Liver

作　　者：邹原[1] 宫德正[1] 崔秀云[1] 梅懋华[1] 

机构地区：[1]大连医科大学生理学教研室,大连医科大学生物化学教研室

出　　处：《生理科学进展》1996年第1期7-12,共6页Progress in Physiological Sciences

摘　　要：肝脏再生过程中受到多种体液因素的调控。肝细胞生长因子（ＨＧＦ）、肝刺激因子（ＨＳＳ）等对肝细胞有促分裂作用；转化生长因子β１（ＴＧＦβ１）等则具有抑制作用。此外，肝再生还需要去甲肾上腺素（ＮＥ）、胰岛素等辅助分裂原的存在，共同调节肝再生。肝细胞分裂增殖与原癌基因表达密切相关。肝细胞从静息期进入细胞周期，以及在整个细胞周期中，某些原癌基因有特征性的表达。There are many humoral factors involved in the control of growth in regenerating liver.The complete hepatocyte mitogens such as hepatocyte growth factor(HGF),hepatic stimulator substance(HSS)can strongly stimulate hepatocyte DNA synthesis and mitosis.The hepatocyte growth inhibitors such as transforming growth factor β1(TGFβ1),however,do not stimulate DNA synthesis.but inhibit EGF mitogenesis. In addition,the comitogens such as norepinephrine and insulin are necessary to regulate the growth of regenerating liver.It has become clear that the hepatocyte proliferation and protooncogenes are linked closely.Some protooncogenes can express specifically as markers in the different phases of the cell cycle and in hepatocytes that enter the cell cycle(G0 to G1 transit)and continue to progress.

关 键 词：肝损伤 肝再生 调控 原癌基因 表达 

分 类 号：R657.302[医药卫生—外科学]