脂联素及受体与非酒精性脂肪性肝炎  

Adiponectin and AdipoR with nonalcoholic steatohepatitis

作　　者：钱晓武[1] 范竹萍[1] 邱德凯[1] 

机构地区：[1]上海交通大学医学院附属仁济医院上海市消化疾病研究所,200001

出　　处：《国际消化病杂志》2006年第3期157-160,共4页International Journal of Digestive Diseases

摘　　要：胰岛素抵抗是非酒精性脂肪性肝炎(NASH)发病机制的关键因素。细胞因子脂联素(adiponectin) 具有增加胰岛素敏感性、抗炎症和抗动脉粥样硬化的作用。而脂联素受体(AdipoR)在adiponectin激活AMPK、增加PPARα配体活性、增加葡萄糖摄取和脂肪酸氧化时发挥介导作用。因此,对adiponectin及AdipoR的进一步研究有助于对NASH的机制和治疗有更好的认识。Insulin resistance play a key role in the pathogenesis of NASH. Adiponectin is an important adipocytokine with insulin-sensitizing, anti-inflammatory and antiatherogenic effect. AdipoR1 and AdipoR2 serve as receptors for globular and full length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator activated receptoral pha ligand activities, and glucose uptake and fatty-acid oxidation by adiponectin. Consequently, further investigation of adiponectin and its receptors would redound to elucidate pathogenesis and therapeutics of NASH .

关 键 词：脂联素 脂联素受体 非酒精性脂肪性肝炎 

分 类 号：R575.1[医药卫生—消化系统]