长期服用苯妥英钠的癫癎患者神经电生理观察  

THE OBSERVATION OF NEUROELECTROPHYSIOLOGY OF PATIENTS WITH EPILEPSY IN LONG-TERM TAKING DILANTIN

作　　者：赵丽梅[1] 张承洁[1] 葛剑青[1] 

机构地区：[1]南京医科大学脑科医院,邮政编码210029

出　　处：《现代电生理学杂志》2006年第2期70-72,共3页Journal of Modern Electrophysiology

摘　　要：目的:观察长期服用苯妥英钠的癫患者周围神经损害。方法:应用丹迪Neuromatic2000M型肌电仪,对37例患者进行正中神经和胫后神经的神经传导(NCV),F波和H反射的检测,同时观察肌肉的针极肌电图(EMG)。结果:癫组与对照组比较正中神经感觉速度(P<0·05),波幅(P<0·05),dML(P<0·05),F波出现率(P<0·01),胫后神经感觉波幅(P<0·05),dML(P<0·01),F波潜伏时(P<0·01)。EMG检测未发现损害。结论:长期服用苯妥英钠的癫患者可发生周围神经损害,表现为(1)感觉运动神经均有损害;(2)脱髓鞘及轴索损害都会发生,轴突损害符合远端轴突病;(3)神经损害远近端都有发生;(4)上下肢神经轴突均有损害,以下肢的轴突损害为重。Objectives： To explore the neuroelectropysiological features of patients with epilepsy in long - term taking dilantin. Methods： Nerve conduction velocity （NCV）, F - wave, H - reflex and electromyography （EMG） of 37 patients with epilepsy were detected. Results： There were significant differences in the NCV between patients and healthy volunteers （P 〈 0. 05） , Conclusions： Long- term taking dilantin could cause damage of peripheral nerve of patients with epilepsy.

关 键 词：苯妥英钠 癫痫 神经传导 

分 类 号：R742.1[医药卫生—神经病学与精神病学]