FDP相关肽修饰物合成与抗栓活性研究  

Studies on the Synthesis and Antithrombosis Activity of the Analogue of Fibrin Decomposed Product-Related Peptide

作　　者：杨国玲[1] 李克勤[1] 胡晓愚 

机构地区：[1]兰州大学生物系

出　　处：《生物化学与生物物理学报》1996年第2期159-163,共5页

摘　　要：采用多肽固相合成法合成了ＦＤＰ相关肽的修饰产物ＨＰＡ，经ＨＰＬＣ鉴定，其纯度为８５．５％，氨基酸组成分析及质谱法测定分子量结果均与理论值相符合。生物活性研究表明，在体外，该肽能有效地抑制ＡＴＰ引起的人血小板聚集作用．在体内，该肽能显著增强家兔血纤溶酶的活性，并能有效抑制家兔实验性血栓的形成。HPA of 85 .5% purity was synthesized by the solid phase method on HPLC.The data obtained from amino acid analysis and fast atom bombardment were in good agreement with the theoretical values. The studies on the biological activity demonstrated that the peptide inhibited efficiently the in vitro ADP-induced human platelet aggregation. In vivo,the peptide increased evidently the activity of plasmin and inhibited experimental thrombosis in the rabbit.

关 键 词：血栓形成 HPA FDP相关肽 血纤维蛋白 降解产物 

分 类 号：R364.15[医药卫生—病理学]