超临界反溶剂过程制备灰黄霉素超细微粒  

Griseofulvin Microparticles by Supercritical Anti-Solvent Process

作　　者：李志义[1] 李文秀[1] 刘学武[1] 孟庭宇[1] 夏远景[1] 

机构地区：[1]大连理工大学流体与粉体工程研究设计所,辽宁大连116012

出　　处：《化学反应工程与工艺》2006年第2期156-161,共6页Chemical Reaction Engineering and Technology

基　　金：国家自然科学基金资助课题(20176003)

摘　　要：超临界反溶剂过程(SAS)是近年来提出的一种制备纳微米粉体的新方法。通过一套超临界反溶剂过程间歇式实验装置,以灰黄霉素、丙酮和二氧化碳系统为研究对象,实验研究了SAS过程参数对制备的微粒形态及其尺寸的影响。当操作条件为10 MPa,40℃,溶液浓度13.3 mg/mL和溶液流速1.5 mL/min时,制备了较为理想的灰黄霉素微粒,粒径分布均匀、形状基本呈球状;当8 MPa,42℃,溶液浓度15 mg/mL和溶液流速4.0 mL/min时,微粒粒径分布比较均一、主要呈细小针状。研究结果表明:采用丙酮作为有机溶剂,可制备出不同大小和形态的灰黄霉素超细微粒。这为改变灰黄霉素传统制剂做了前期准备工作,为制成可持缓释药物提供了可能性。Supercritical anti-solvent （SAS） process was proposed recently as a new technique to produce micro-and nano-particles. The effects of the SAS process parameters on particle morphology and its size were evaluated in the Griseofulvin-aeetone-CO2 system by semi-continuous supercritical antisolvent precipitation apparatus. Uniform and spherical griseofulvin microparticles were observed at 10 MPa, 40 ℃, griseofulvin concentration in acetone of 13. 3 mg/mL, the solution flow-rate of 1.5 mL/min. Most of griseofulvin micropartieles were uniform and needlelike at 8 MPa, 42℃, griseofulvin concentration in acetone of 15 mg/mL, the solution flow-rate of 4. 0 mL/min. Experimental results showed that griseofulvin microparticles of different sizes and morphologies could be obtained through SAS process when acetone was used as organic solvent. This method would be a preparative process for griseofulvin precipitation. It would make produce the sustained-release drug possible.

关 键 词：超临界反溶剂过程 超细微粒 灰黄霉素 

分 类 号：TQ029.1[化学工程] R978.1[医药卫生—药品]