氯丙嗪与利培酮对人体姿态平衡效应的对照研究  

A controlled study of compared chlorpromazine with risperidone effect on body posture balance

作　　者：王筱兰[1] 徐捷[1] 喻东山[1] 成为荣[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《四川精神卫生》2006年第3期144-146,共3页Sichuan Mental Health

基　　金：南京市跨世纪学科带头人后备人员专项基金资助项目(20028055)

摘　　要：目的比较氯丙嗪与利培酮对人体姿态平衡的效应。方法对象为79例精神分裂症患者,其中40例用氯丙嗪治疗,39例用利培酮治疗;两组分别在治疗第3天与第28天时,应用人体姿态平衡仪检测,以及在入组与治疗第28天时,分别采用简明精神病量表测评。结果①在治疗第3天,氯丙嗪组(100mg/d)的路径总长比利培酮组(1mg/d)明显为长[(1052±298)mm:(795±160)mm,P<0.001];Romberg路径比比利培酮组明显为大[(1.26±0.25):(1.14±0.18),P<0.05]。②在治疗第28天时,氯丙嗪组[(386.7±86)mg/d]的外围面积和Romberg面积比比利培酮组[(3.6±0.9)mg/d]明显为大[(483±303)mm2:(351±199)mm2;(1.6±0.7):(1.2±0.6),P均<0.05];路径总长也显著大于利培酮组[(1090±258)mm:(734±144)mm,P<0.001]。③两组在治疗第3天和第28天时,平衡试验参数与精神病症状之间均无显著相关性(P>0.05)。结论在第3天低剂量治疗时,氯丙嗪组对姿态平衡功能的损害大于利培酮;在第28天治疗量时,氯丙嗪组对平衡功能的损害进一步大于利培酮组。平衡功能的改变与精神分裂症的症状之间无关。Objective To compared ehlorpromazine with risperidone effect on body posture balance. Methods Body posture balance test was estimated in 40 schizophrenics taking chlorpromazine and 39 schizophrenics taking risperidone at posttreatment 3^rd and 28^th day, respectively. BPRS was also estimated in the chlorpromazine group and the risperidone group at the pretreatment and posttreatment 28^th day, respectively. Results At postteatment 3^rd day, track total distance was significantly longer in patients taking chlorpromazine（100mg/d） than patients taking risperidone （1 mg/d） [ （1052 ± 298 ）mm vs （795 ± 160） ram, P 〈 0. 001 ] and it was significantly larger for ratio of Romberg track distance in patients taking chlorpromazine than patients taking risperidone [ （ 1.26 ± 0. 25 ） vs （ 1.14 ± 0. 18 ）, P 〈 0. 05 ]. At posttreatment 28^th day, the surround area and the ratio of Romberg area （ blind the eyes/open the eyes） were significantly larger in patients taking chlorpromazine [ （386.7 ± 86） mg/d] than patients taking risperidone[ （3.6±0. 9） mg/d] [ （483 ± 303） mm^2 vs（351 ± 199）mm^2 ,（1.6 ± 0. 7）vs （ 1. 2 ± 0. 6 ）, P 〈 0.05 ] ;track total distance was also significantly longer in patients taking chlorpromazine than patients taking risperidone [ （ 1090 ± 258 ）mm vs（ 734 ± 144） ram, P 〈 0. 001 ]. There were no significant correlations between psychotic symptoms and the parameters of balance test at posttreatment 3^rd and 28^th day in two groups. Conclusion At posttreatment 3^rd day, there was more damage for posture balance function in patients taking chiorpromazine than patients taking risperidone;At posttreatment 28^th day, the damage was more prominent; There was no relationship between the damage of balance function and schizophrenic symptoms.

关 键 词：氧丙嗪 利培酮 精神分裂症 人体姿态平衡效应 

分 类 号：R749.053[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]