瑞美隆与氯丙咪嗪治疗抑郁焦虑症状的对照研究  

Controlled study of Remeron and Clomipramine on depressive with anxiety

作　　者：陈宏[1] 郭晗峰[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《现代中西医结合杂志》2006年第13期1736-1737,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的比较瑞美隆、氯丙咪嗪治疗抑郁同时伴有焦虑症状的门诊抑郁伴焦虑患者的疗效及不良反应。方法对70例抑郁伴焦虑患者进行瑞美隆和氯丙咪嗪对照治疗,其中瑞美隆组(简称A组)34例(30 mg/d),氯丙咪嗪组(简称B组)36例(150 mg/d);共治疗4周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定临床疗效,采用副反应量表(TESS)评定不良反应。结果瑞美隆疗效优于氯丙咪嗪,两者有显著性差异。瑞美隆不良反应明显少于氯丙咪嗪。结论瑞美隆治疗抑郁焦虑症状的疗效强于氯丙咪嗪,不良反应较轻,耐受性好。Objective it is to compare the curative effect and untoward reaction of Remeron and Clomipramine on depressive with anxiety. Methods Seventy patients with depression and anxiety were treated and compared with and Clomipramine for four weeks. 34 cases in group A were treated with Remeron 30 mg/d and 36 cases in group B were treated with Clomipramine 150 mg/d. Clinical curative effect was evaluated with HADM and HAMA, and untoward reaction was evalu- ated with TESS. Results The curative effect of Remeron was outstripped to that of Clomipramine and there was significant difference. The untoward reaction of Remeron was obviously fewer than that of Clomipramine. Conclusion The curative effect of Remeron on depression with anxiety is outstripped to that of Clomipramine, the untoward reaction is lighter and the toleration is good.

关 键 词：瑞美隆 氯丙咪嗪 抑郁焦虑症状 不良反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]