胃癌组织中Her-2/neu和E-cadherin的表达及临床意义  

Expressions of Her-2/neu, E-cadherin and their significance in gastric carcinoma

作　　者：刘丰基[1] 王元洪[2] 王潍博[1] 

机构地区：[1]山东大学医学院山东省立医院化疗科,山东济南250021 [2]山东莱芜钢铁集团有限公司医院内科,山东莱芜271105

出　　处：《中华肿瘤防治杂志》2006年第11期847-850,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的探讨胃癌组织中Her-2/neu和E-cadherin的表达情况及在胃癌发生发展及侵袭转移中的作用。方法应用SP法研究112例胃癌及40例正常胃黏膜组织中Her-2/neu和E-cadherin的表达。结果胃癌组织中Her-2/neu阳性表达率为20·5%(23/112),E-cadherin阳性表达率为34·0%(38/112);40例正常胃黏膜阳性表达率Her-2/neu为5·0%(2/40),E-cadherin为100·0%(40/40)。胃癌Her-2/neu阳性表达率显著高于正常胃黏膜组织,χ2=5·17,P<0·05;正常胃黏膜E-cadherin阳性表达率显著高于胃癌阳性表达率,χ2=18·11,P<0·01。胃癌组织中Her-2/neu的表达与胃癌分化程度(χ2=4·82,P<0·05)、TNM分期(χ2=5·37,P<0·05)、淋巴结转移数(χ2=6·42,P<0·05)及浆膜浸润(χ2=7·30,P<0·01)显著相关。胃癌组织中E-cadherin的表达与胃癌分化程度(χ2=14·40,P<0·01)和淋巴结转移(χ2=29·27,P<0·01)呈负相关,但与TNM分期(χ2=1·31,P>0·05)和有无浆膜浸润(χ2=2·62,P>0·05)均无显著相关。结论Her-2/neu和E-cadherin在胃癌的发生发展及侵袭转移中起重要作用,对两者的检测有助于对患者预后的判断。OBJECTIVE： To study the significance of Her-2/neu and E-cadherin the initiation, development, invasion and metastasis of gastric carcinoma. METHODS： The expressions of Her-2/neu and E-cadherin in 112 cases of gastric carcinoma （GC） and 40 cases of normal control were studied with SP immunohistochemical method. RESULTS： The positive rates of Her-2/neu and E-cadherin in GC were 20.5% （23/112） and 34.0% （38/112） respectively. While the positive rates of Her-2/nen and E-cadherin in normal control were 5.0% （2/40）, 100.0% （40/40） respectively. The expression of Her-2/neu in GC was higher than that in normal control （X^2 = 5.17, P 〈 0.05） and the expression of E-cadherin in normal control was higher than that in GC （X^2 = 18.11, P 〈 0.01）. The expression of Her-2/neu was significantly correlated with the clinicopathological factors such as differentiation （X^2 = 4.84, P 〈 0.05）, lymph node metastasis （X^2 = 6.42, P 〈 0.05）, clinical stage （X^2 = 5.37, P 〈0.05） and depth of invasion （X^2 = 7.30, P 〈 0.01）. The expression of E-cadherin was significantly correlated with differentiation （X^2 = 14.40, P 〈 0.01） and lymph node metastasis （X^2 = 29.27, P 〈 0.01）, but no correlation was observed between E-cad- herin and depth of invasion （X^2 = 2.62, P 〈 0.05） and clinical stages （X^2 = 1.31, P 〈 0.05）. CONCLUSIONS： Her-2/neu and E-cadherin may play important roles in initiation, development, invasion metastasis of gastric carcinoma. They are useful markers of the patients with GC.

关 键 词：胃肿瘤 受体 表皮生长因子 钙粘着糖蛋白 免疫组织化学 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]