鼻咽清毒颗粒加鼻渊舒口服液抑制鼻咽癌高危人群EB病毒VCA/IgA的临床观察  

Clinical study of bi yan qing du ke li and nasosinusitis relieving oral liquid in treatment of EB virus VCA/IgA titers in patients with high risk of nasopharyngeal carcinoma

作　　者：郭长凯[1] 孔维佳[1] 余青松[1] 张松[1] 李擎天[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,湖北武汉430022

出　　处：《中华肿瘤防治杂志》2006年第10期729-732,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家杰出青年科学基金资助(39925035)

摘　　要：目的:观察鼻咽清毒颗粒加鼻渊舒口服液对鼻咽癌高危人群EB病毒壳抗原抗体VCA/IgA的抑制作用。方法:将136例鼻咽癌高危患者按就诊顺序分成实验组(鼻咽清毒颗粒加鼻渊舒口服液组)76例和对照组(鼻咽清毒颗粒组)60例。两组在治疗前均经电子鼻咽镜检查和鼻咽部活检排除有鼻咽癌。结果:实验组和对照组治疗前EB病毒VCA/IgA几何平均滴度分别为1∶38.04和1∶30.80,两组几何平均滴度基本一致,u=1.18,P=0.320。治疗后,实验组76例患者中痊愈42例(55.3%)、显效16例(21.0%)、有效10例(13.2%)及无效8例(10.5%),未见任何不良反应;对照组60例患者中痊愈10例(16.7%)、显效4例(6.6%)、有效10例(16.7%)及无效36例(60.0%)。两组疗效比较差异有统计学意义,u=4.2,P=0.000。治疗后,对照组VCA/IgA几何平均滴度降至1∶22.15,鼻咽清毒颗粒对EB病毒VCA/IgA滴度水平影响不大,u=1.34,P=0.220;而实验组VCA/IgA几何平均滴度降至1∶8.26,鼻咽清毒颗粒加用鼻渊舒口服液能显著性降低鼻咽癌高危人群EB病毒VCA/IgA滴度水平,u=8.92,P=0.000。结论:鼻咽清毒颗粒加用鼻渊舒口服液对鼻咽癌高危人群EB病毒VCA/IgA滴度水平有明显的抑制作用,有助于降低鼻咽癌的发病率。OBJECTIVE： To investigate the effect of application of bi yan qing duke li combined with nasosinusitis relieving oral liquid on EB virus VCA/IgA titers in patients with the high risk of nasopharyngeal carcinoma （NPC）. METHODS： A total of 136 patients who belonged to the high-risk population of NPC with high antibody titers of VCA/IgA were randomly divided into a study group （bi yan qing du ke li combined with nasosinusitis relieving oral liquid group, n=76） and a control group （bi yan qing duke li group, n= 60） according to the visit time. RESULTS： The geometric mean titers （GMT） of VCA/IgA were 1 ： 38. 04 in the study group and 1 ： 30.80 in the control group （u=l. 18, P=0. 320） before treatment. The recovery rates of nasopharyngeal symptoms after the treatment were 55.3% in the study group and 16.7% in the control group, respectively （u=4.2, P=0.000）. The GMT： of VCA/IgA after treatment were 1 ： 8. 26 in the study group and 1 ： 22.15 in the control group, respectively. No statistical significance was found in the control group （u= 1.34, P= 0. 220）, however, an important inhibition effect was found in the study group （u=8. 92,P=0. 000）. CONCLUSIONS： The application of bi yan qing duke li combined with nasosinusitis relieving oral liquid can significantly decrease the titers of VCA/IgA in patients with the high risk of NPC, which is helpful to decrease the incidence rate of NPC.

关 键 词：鼻咽肿瘤/中药疗法 抗体 病毒/分析 疤疹病毒4型 人/免疫学 滴定分析法 危重病 

分 类 号：R739.63[医药卫生—肿瘤]