Lewy体病患者损伤心肌对^(123)I-间碘苄胍的摄取情况:Lewy体型痴呆和帕金森病的比较  

Impaired myocardial ^(123)I-metaiodobenzylguanidine uptake in Lewy body disease: Comparison between dementia with Lewy bodies and Parkinson's disease

作　　者：Suzuki M Kurita A Hashimoto M 高艳琼 

机构地区：[1]Department of Neurology, Jikei University, School of Medicine, 3- 25- 8, Nishi-Shinbashi, Minato-ku, Tokyo 1058461, Japan

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第5期52-52,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background: Iodine- 123- labeled metaiodobenzylguanidine ( 123I- MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD) including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Patients with LBD had marked reductions in cardiac MIBG accumulation, indicative of severe impairment of the cardiac sympathetic nervous systems. However, the differences in scintigraphy between DLB and PD have not been determined. Objective: To compare cardiac sympathetic function in early disease stage measured with 123I- MIBG scintigraphy between DLB and PD. Methods: 123I- MIBG myocardial scintigraphy was performed in 22 patients with early-stage DLB, 41 patients with early idiopathic PD and 15 normal control subjects who were matched for age and disease duration. The heart-to-mediastinum (H/M) ratio was calculated. Results: 123I- MIBG uptake of the myocardium was significantly lower in patients with early DLB than in controls. The mean value of H/M ratio in patients with DLB was significantly lower than those in patients with PD, independent of the Hoehn and Yahr stage. Conclusions: Our findings suggest that cardiac sympathetic function in DLB is severely impaired even in the early disease stage.Background： Iodine - 123 - labeled metaiodobenzylguani- dine （ ^123I- MIBG） myocardial seintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease （LBD） including Parkinson＇s disease （PD） and dementia with Lewy bodies （DLB）. Patients with LBD had marked reductions in cardiac MIBG accumulation, indicative of severe impairment of the cardiac sympathetic hervous systems. However, the differences in scintigraphy between DLB and PD have not been determined. Objective： To compare cardiac sympathetic function in early disease stage measured with ^123I- MIBG scintigraphy between DLB and PD. Methods：^123I- MIBG myocardial scintigraphy was performed in 22 patients with early-stage DLB, 41 patients with early idiopathic PD and 15 normal control subjects who were matched for age and disease duration. The heart-to-mediastinum （H/M） ratio was calculated. Results：^123I - MIBG uptake of the myocardium was significantly lower in patients with early DLB than in controis. The mean Value of H/M ratio in patients with DLB was significantly lower than those in patients with PD, independent of the Hoehn and Yahr stage. Conclusions： Our findings suggest that cardiac sympathetic function in DLB is severely impaired even in the early disease stage.

关 键 词：LEWY体病 帕金森病 间碘苄胍 患者 心肌 摄取 痴呆 体型 损伤 心脏交感神经 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]