内镜缝合术在反流性食管炎中的临床应用研究  

Endoscopic Suturing Therapy for Gastroesophageal Reflux Disease

作　　者：王炳周[1] 吴灵飞[1] 罗碧芳[1] 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《河北医学》2006年第6期488-489,共2页Hebei Medicine

基　　金：汕头市2003年重点科研项目立项:汕府科[2003]119

摘　　要：目的:探讨内镜缝合术在反流性食管炎中的应用价值及该术的安全性。方法:对经内镜、食管ph鉴测、食管测压、临床症状等确诊并且有质子泵抑制剂依赖的11例胃食管反流病(其中贲门切除术后胃食管反流2例),应用美国BARD内镜缝合系统行内镜下贲门缝合术,观察术前术后胃食管反流的积分情况及该术的并发症等项目,对该术的短期疗效及安全性进行评价。结果:11例患者共缝合26针,13个结,其中纵行缝合4例次,环行缝合9例次。术后症状完全缓解的5例,部分缓解的4例,无效2例。除术中缝合处针孔少许渗血外,术中及术后患者均未出现明显并发症。结论:内镜缝合术近期疗效可靠,安全性好,远期疗效有待进一步研究。Objective： This study was to evaluate prospectively the feasibility and efficacy of endoscopic suturing therapy for gastroesophageal reflux disease. Method： The study involved 9 patients with gastroesophageal with resec reflux disease （ GERD ） that required proton pump inhibitor （ PPI） treatment, including 2 patients tion of cardiac orifice. Using BARD Endoscopic Suturing Device, plications were created at the gastroesophageal junction. Patients underwent endoscopy, 24 -hour pH monitoring and esophageal manometry before treatment and 3 months afterwards. In addition, reflux symptoms as well as quality - of - life scores were assessed. Result： Thirteen procedures were finished in eleven patients. The plicae were sutured on the lesser curve with linear configuration in 4 patients,around the cardiac with circumferential configuration in 9 cases. The heart burn and regurgitation were significant changes in 5 patients and remitted partly in 4 cases. The procedure was performed successfully in all patients without major complications except. Conclusion： Endoscopic suturing therapy for gastroesophageal reflux disease is an easy and safe treatment. Its initial results have been promising, the long - term durability of the treatment is uncertain.

关 键 词：内镜缝合术 反流性食管炎 

分 类 号：R571[医药卫生—消化系统]